CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015626
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isoamyl acetate-hydrolyzing esterase 1 homolog 
Protein Synonyms/Alias
 Hypertrophic agonist-responsive protein B64 
Gene Name
 Iah1 
Gene Synonyms/Alias
 Harpb64 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
63GYNTRWAKIILPRIIacetylation[1]
125LRSVDIPKERVILITacetylation[1]
232PRLLPDWKDVEETKPacetylation[1]
238WKDVEETKPELSLLGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Probable lipase (By similarity). 
Sequence Annotation
 ACT_SITE 24 24 Nucleophile (By similarity).
 ACT_SITE 197 197 By similarity.
 ACT_SITE 200 200 By similarity.
 BINDING 56 56 Substrate; via amide nitrogen (By
 BINDING 89 89 Substrate (By similarity).  
Keyword
 Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 249 AA 
Protein Sequence
MSLCELAASG SSLLWPRVLL FGDSITQFSF QQGGWGTLLA DRLVRKCDVL NRGFSGYNTR 60
WAKIILPRII RKGAGLENPV AVTIFFGAND STLKDENPKQ HVPLDEYSAN LRDMVQYLRS 120
VDIPKERVIL ITPPPLCEAA WEKECILKGC KLNRLNVAVG EYAKACLQVA RDCGTDVLDL 180
WTLMQKDNQD FSSYLSDGLH LSPLGNEFLF FHLWPLLDKK VSSLPRLLPD WKDVEETKPE 240
LSLLGDGDH 249 
Gene Ontology
 GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR001087; Lipase_GDSL.
 IPR013831; SGNH_hydro-type_esterase_dom. 
Pfam
 PF00657; Lipase_GDSL 
SMART
  
PROSITE
 PS01098; LIPASE_GDSL_SER 
PRINTS