CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037017
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Kinetochore-associated protein 1 
Protein Synonyms/Alias
  
Gene Name
 KNTC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43LVKISSEKASLNPKIubiquitination[1, 2, 3]
185NVDFSTAKKGTGNCAubiquitination[2]
217LIDAEIIKGAKKFQLubiquitination[2]
400KSNHILEKLALSSVDubiquitination[1]
422QQLVDDAKENLHKIQubiquitination[1]
457QEMLNYAKTRLLKKEubiquitination[1, 3]
476LIYSDGLKEVLRAHAubiquitination[1, 3]
568QKLCPWFKNDVIPFVubiquitination[2, 4]
588EGQIILAKWLEQAARubiquitination[2, 5]
676LALSDFEKENTTTIVubiquitination[1]
689IVFRMFDKVLAPELIacetylation[6]
689IVFRMFDKVLAPELIubiquitination[1]
702LIPSILEKFIRVYMRubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1134 AA 
Protein Sequence
MWNDIELLTN DDTGSGYLSV GSRKEHGTAL YQVDLLVKIS SEKASLNPKI QACSLSDGFI 60
IVADQSVILL DSICRSLQLH LVFDTEVDVV GLCQEGKFLL VGERSGNLHL IHVTSKQTLL 120
TNAFVQKAND ENRRTYQNLV IEKDGSNEGT YYMLLLTYSG FFCITNLQLL KIQQAIENVD 180
FSTAKKGTGN CAFSKWEPDS SKKGMTVKNL IDAEIIKGAK KFQLIDNLLF VLDTDNVLSL 240
WDIYTLTPVW NWPSLHVEEF LLTTEADSPS SVTWQGITNL KLIALTASAN KKMKNLMVYS 300
LPTMEILYSL EVSSVSSLVQ TGISTDTIYL LEGVCKNDPK LSEDSVSVLV LRCLTEALPE 360
NRLSRLLHKH RFAEAESFAI QFGLDVELVY KVKSNHILEK LALSSVDASE QTEWQQLVDD 420
AKENLHKIQD DEFVVNYCLK AQWITYETTQ EMLNYAKTRL LKKEDKTALI YSDGLKEVLR 480
AHAKLTTFYG AFGPEKFSGS SWIEFLNNED DLKDIFLQLK EGNLVCAQYL WLRHRANFES 540
RFDVKMLESL LNSMSASVSL QKLCPWFKND VIPFVRRTVP EGQIILAKWL EQAARNLELT 600
DKANWPENGL QLAEIFFTAE KTDELGLASS WHWISLKDYQ NTEEVCQLRT LVNNLRELIT 660
LHRKYNCKLA LSDFEKENTT TIVFRMFDKV LAPELIPSIL EKFIRVYMRE HDLQEEELLL 720
LYIEDLLNRC SSKSTSLFET AWEAKAMAVI ACLSDTDKPS ELFELQEDEA LRRVQYLLLS 780
RPIDYSSRML FVFATSTTTT LGMHQLTFAH RTRALQCLFY LADKETIESL FKKPIEEVKS 840
YLRCITFLAS FETLNIPITY ELFCSSPKEG MIKGLWKNHS HESMAVRLVT ELCLEYKIYD 900
LQLWNGLLQK LLGFNMIPYL RKVLKAISSI HSLWQVPYFS KAWQRVIQIP LLSASCPLSP 960
DQLSDCSESL IAVLECPVSG DLDLIGVARQ YIQLELPAFA LACLMLMPHS EKRHQQIKNF 1020
LGSCDPQVIL KQLEEHMNTG QLAGFSHQIR SLILNNIINK KEFGILAKTK YFQMLKMHAM 1080
NTNNITELVN YLANDLSLDE ASVLITEYSK HCGKPVPPDT APCEILKMFL SGLS 1134 
Gene Ontology
  
Interpro
 IPR019527; RZZ-complex_KNTC1/ROD_C. 
Pfam
 PF10493; Rod_C 
SMART
  
PROSITE
  
PRINTS