UniProt Accession

 ZNF22_MOUSE; Q9ERU3; Q3TF83; Q8VEK7 

Genbank Protein ID

 AF281634; AK082970; AK169251; BC018339 

Genbank Nucleotide ID

 AAG12466.1; BAC38716.1; BAE41015.1; AAH18339.1 

Protein Name

 Zinc finger protein 22 

Protein Synonyms/Alias

 Zinc finger protein 422; Zinc finger protein Krox-25; Zinc finger protein Krox-26 

Gene Name

 Znf22 

Gene Synonyms/Alias

 Krox25; Krox26; Zfp422 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
18	SRSASQGKAYESKRK	acetylation	[1, 2]
23	QGKAYESKRKTARQR	acetylation	[2]
137	QRIHTGEKPYCCDEC	acetylation	[3]
165	QRTHTGEKPYQCEEC	acetylation	[3]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation. 

Sequence Annotation

 ZN_FING 55 77 C2H2-type 1.
 ZN_FING 83 105 C2H2-type 2.
 ZN_FING 111 133 C2H2-type 3.
 ZN_FING 139 161 C2H2-type 4.
 ZN_FING 167 189 C2H2-type 5.  

Keyword

 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 237 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0042476; P:odontogenesis; NAS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS