CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005014
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyruvate dehydrogenase E1 component subunit alpha 
Protein Synonyms/Alias
 S complex, 42 kDa subunit; Vegetative protein 220; VEG220 
Gene Name
 pdhA 
Gene Synonyms/Alias
 aceA; BSU14580 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
287DPTKYRTKEIENEWEacetylation[1]
325AKVIEDAKEEIKQAIacetylation[1]
348QKVTDLMKIMYEKMPacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). 
Sequence Annotation
  
Keyword
 Complete proteome; Direct protein sequencing; Glycolysis; Oxidoreductase; Pyruvate; Reference proteome; Thiamine pyrophosphate. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 371 AA 
Protein Sequence
MAAKTKKAIV DSKKQFDAIK KQFETFQILN EKGEVVNEAA MPDLTDDQLK ELMRRMVFTR 60
VLDQRSISLN RQGRLGFYAP TAGQEASQIA THFALEKEDF VLPGYRDVPQ LIWHGLPLYQ 120
AFLFSRGHFR GNQMPDDVNA LSPQIIIGAQ YIQTAGVALG LKKRGKKAVA ITYTGDGGAS 180
QGDFYEGINF AGAYKAPAIF VVQNNRYAIS TPVEKQSAAE TIAQKAVAAG IVGVQVDGMD 240
PLAVYAATAE ARERAINGEG PTLIETLTFR YGPHTMAGDD PTKYRTKEIE NEWEQKDPLV 300
RFRAFLENKG LWSEEEEAKV IEDAKEEIKQ AIKKADAEPK QKVTDLMKIM YEKMPHNLEE 360
QFEIYTQKES K 371 
Gene Ontology
 GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:EC.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001017; DH_E1.
 IPR017596; Pyrv_DH_E1_asu_subgrp-x. 
Pfam
 PF00676; E1_dh 
SMART
  
PROSITE
  
PRINTS