CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014627
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Copper-transporting ATPase 2 
Protein Synonyms/Alias
 Copper pump 2; Wilson disease-associated protein homolog 
Gene Name
 Atp7b 
Gene Synonyms/Alias
 Wnd 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
442INPVRNFKSGNSVPQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile (By similarity). 
Sequence Annotation
 DOMAIN 69 135 HMA 1.
 DOMAIN 154 220 HMA 2.
 DOMAIN 268 334 HMA 3.
 DOMAIN 362 428 HMA 4.
 DOMAIN 491 557 HMA 5.
 DOMAIN 567 633 HMA 6.
 ACT_SITE 1029 1029 4-aspartylphosphate intermediate (By
 METAL 79 79 Copper 1 (By similarity).
 METAL 82 82 Copper 1 (By similarity).
 METAL 164 164 Copper 2 (By similarity).
 METAL 167 167 Copper 2 (By similarity).
 METAL 278 278 Copper 3 (By similarity).
 METAL 281 281 Copper 3 (By similarity).
 METAL 372 372 Copper 4 (By similarity).
 METAL 501 501 Copper 5 (By similarity).
 METAL 504 504 Copper 5 (By similarity).
 METAL 577 577 Copper 6 (By similarity).
 METAL 580 580 Copper 6 (By similarity).
 METAL 1264 1264 Magnesium (By similarity).
 METAL 1268 1268 Magnesium (By similarity).  
Keyword
 ATP-binding; Complete proteome; Copper; Copper transport; Disease mutation; Golgi apparatus; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1462 AA 
Protein Sequence
MDPRKNLASV GTMPEQERQV TAKEASRKIL SKLALPGRPW EQSMKQSFAF DNVGYEGGLD 60
STSSSPAATD VVNILGMTCH SCVKSIEDRI SSLKGIVNIK VSLEQGSATV RYVPSVMNLQ 120
QICLQIEDMG FEASAAEGKA ASWPSRSSPA QEAVVKLRVE GMTCQSCVSS IEGKIRKLQG 180
VVRIKVSLSN QEAVITYQPY LIQPEDLRDH ICDMGFEAAI KNRTAPLRLG PIDVNKLEST 240
NLKKETVSPV QISNHFETLG HQGSYLATLP LRIDGMHCKS CVLNIEGNIG QLPGVQNIHV 300
SLENKTAQIQ YDPSCVTPMF LQTAIEALPP GHFKVSLPDG VEENEPQSGS SQRHQEQGPG 360
RTAVLTISGI TCASSVQPIE DMLSQRKGVQ QTSISLAEGT GAVLYDPSIV SLDELRTAVE 420
DMGFEVSVNS ETFTINPVRN FKSGNSVPQT MGDIAGSVQK MAPDTRGLPT HQGPGHSSET 480
PSSPGATASQ KCFVQIKGMT CASCVSNIER SLQRHAGILS VLVALMSGKA EVKYDPEIIQ 540
SPRIAQLIQD LGFEASVMED NTVSEGDIEL IITGMTCASC VHNIESKLTR TNGITYASVA 600
LATSKAHVKF DPEIVGPRDI IKIIEEIGFH ASLAQRNPNA HHLDHKTEIK QWKKSFLCSL 660
VFGIPVMGLM VYMLIPSSTP QETMVLDHNI IPGLSVLNLI FFILCTFVQF LGGWYFYVQA 720
YKSLRHRSAN MDVLIVLATT IAYAYSLVIL VVAVAEKAEK SPVTFFDTPP MLFVFIALGR 780
WLEHVAKSKT SEALAKLMSL QATEATVVTL GEDNLILREE QVPMELVQRG DVIKVVPGGK 840
FPVDGKVLEG NTMADESLIT GEAMPVTKKP GSIVIAGSIN AHGSVLLKAT HVGNDTTLAQ 900
IVKLVEEAQM SKAPIQQLAD RFSGYFVPFI IIISTLTLVV WIVIGFVDFG VVQKYFPSPS 960
KHISQTEVII RFAFQTSITV LCIACPCSLG LATPTAVMVG TGVAAQNGVL IKGGKPLEMA 1020
HKIKTVMFDK TGTITHGVPR VMRFLLLADV ATLPLRKVLA VVGTAEASSE HPLGVAVTKY 1080
CKEELGTETL GYSTDFQAVP GCGISCKVSN VEGILARSDL TAHPVGVGNP PTGEGAGPQT 1140
FSVLIGNREW MRRNGLTISS DISDAMTDHE MKGQTAILVA IDGVLCGMIA IADAVKPEAA 1200
LAIYTLKSMG VDVALITGDN RKTARAIATQ VGINKVFAEV LPSHKVAKVQ ELQNEGKKVA 1260
MVGDGVNDSP ALAQADVGIA IGTGTDVAIE AADVVLIRND LLDVVASIHL SKRTVRRIRV 1320
NLVLALIYNM VGIPIAAGVF MPIGIVLQPW MGSAAMAASS VSVVLSSLQL KCYRKPDLER 1380
YEAQAHGRMK PLSASQVSVH IGMDDRRRDS PRATAWDQVS YVSQVSLSSL TSDRLSRHGG 1440
AAEDGGDKWS LLLSDRDEEQ CI 1462 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005770; C:late endosome; ISS:UniProtKB.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IDA:MGI.
 GO:0005524; F:ATP binding; ISS:HGNC.
 GO:0005507; F:copper ion binding; ISS:HGNC.
 GO:0004008; F:copper-exporting ATPase activity; IDA:MGI.
 GO:0006878; P:cellular copper ion homeostasis; IMP:MGI.
 GO:0006882; P:cellular zinc ion homeostasis; IMP:MGI.
 GO:0015677; P:copper ion import; IEA:Compara.
 GO:0015680; P:intracellular copper ion transport; IMP:MGI.
 GO:0007595; P:lactation; IMP:MGI.
 GO:0046688; P:response to copper ion; IEA:Compara.
 GO:0051208; P:sequestering of calcium ion; IEA:Compara. 
Interpro
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR027256; Cation_transp_P-typ_ATPase_IB.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom.
 IPR017969; Heavy-metal-associated_CS.
 IPR006121; HeavyMe-assoc_HMA.
 IPR006122; HMA_Cu_ion-bd. 
Pfam
 PF00122; E1-E2_ATPase
 PF00403; HMA
 PF00702; Hydrolase 
SMART
  
PROSITE
 PS00154; ATPASE_E1_E2
 PS01047; HMA_1
 PS50846; HMA_2 
PRINTS
 PR00119; CATATPASE.