CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011661
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitotic-spindle organizing protein 1 
Protein Synonyms/Alias
 Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1 
Gene Name
 MZT1 
Gene Synonyms/Alias
 C13orf37; MOZART1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
65EALSSVIKELRKATEubiquitination[1, 2, 3, 4, 5]
69SVIKELRKATEALKAubiquitination[6]
75RKATEALKAAENMTSubiquitination[2, 4, 5, 6]
Reference
 [1] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Required for gamma-tubulin complex recruitment to the centrosome. 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 82 AA 
Protein Sequence
MASSSGAGAA AAAAAANLNA VRETMDVLLE ISRILNTGLD METLSICVRL CEQGINPEAL 60
SSVIKELRKA TEALKAAENM TS 82 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0008274; C:gamma-tubulin ring complex; IDA:UniProtKB.
 GO:0005819; C:spindle; IDA:UniProtKB.
 GO:0033566; P:gamma-tubulin complex localization; IMP:UniProtKB. 
Interpro
 IPR022214; DUF3743. 
Pfam
 PF12554; MOZART1 
SMART
  
PROSITE
  
PRINTS