CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037509
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Phosphatidylinositol-binding clathrin assembly protein 
Protein Synonyms/Alias
  
Gene Name
 PICALM 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
61NLSNFLDKSGLQGYDubiquitination[1]
83YSRYLNEKAVSYRQVubiquitination[1, 2, 3, 4]
112MRTMNTEKLLKTVPIubiquitination[3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 148 AA 
Protein Sequence
MNVNIPQLAD SLFERTTNSS WVVVFKSLIT THHLMVYGNE RFIQYLASRN TLFNLSNFLD 60
KSGLQGYDMS TFIRRYSRYL NEKAVSYRQV AFDFTKVKRG ADGVMRTMNT EKLLKTVPII 120
QNQMDALLDF NVNSNELTNG VINAAFML 148 
Gene Ontology
 GO:0030118; C:clathrin coat; IEA:InterPro.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
 GO:0007409; P:axonogenesis; IEA:Compara.
 GO:0048268; P:clathrin coat assembly; IEA:InterPro.
 GO:0048813; P:dendrite morphogenesis; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara. 
Interpro
 IPR011417; ANTH_dom.
 IPR014712; Clathrin_Pinositid-bd_GAT-like.
 IPR008942; ENTH_VHS.
 IPR013809; Epsin-like_N. 
Pfam
 PF07651; ANTH 
SMART
  
PROSITE
 PS50942; ENTH 
PRINTS