CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033254
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 UBX domain-containing protein 7 
Protein Synonyms/Alias
  
Gene Name
 UBXN7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
32VWSNEAVKNIIREHFubiquitination[1, 2, 3]
59QRYIQFYKLGDFPYVubiquitination[4, 5, 6]
147HFDSTQTKQDSRSDEubiquitination[5]
272ITLPEQAKLLALVKHacetylation[7]
278AKLLALVKHVQSKGYubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 327 AA 
Protein Sequence
MQNKWLMINI QNVQDFACQC LNRDVWSNEA VKNIIREHFI FWQVYHDSEE GQRYIQFYKL 60
GDFPYVSILD PRTGQKLVEW HQLDVSSFLD QVTGFLGEHG QLDGLSSSPP KKCARSESLI 120
DASEDSQLEA AIRASLQETH FDSTQTKQDS RSDEESESEL FSGSEEFISV CGSDEEEEVE 180
NLAKSRKSPH KDLGHRKEEN RRPLTEPPVR TDPGTATNHQ GLPAVDSEIL EMPPEKADGV 240
VEGIDVNGPK AQLMLRYPDG KREQITLPEQ AKLLALVKHV QSKGYPNERF ELLTNFPRRK 300
LSHLDYDITL QEAGLCPQET VFVQERN 327 
Gene Ontology
  
Interpro
 IPR012336; Thioredoxin-like_fold.
 IPR006577; UAS.
 IPR001012; UBX. 
Pfam
 PF00789; UBX 
SMART
 SM00594; UAS
 SM00166; UBX 
PROSITE
 PS50033; UBX 
PRINTS