| Tag | Content |
|---|
| CPLM ID | CPLM-028321 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histidinol dehydrogenase |
Protein Synonyms/Alias | HDH |
Gene Name | hisD |
Gene Synonyms/Alias | MSMEG_3205 |
Created Date | July 27, 2013 |
Organism | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) |
NCBI Taxa ID | 246196 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 41 | DVDAVVPKVRPIVDA | pupylation | [1] |
|
Reference | [1] Proteome-wide identification of mycobacterial pupylation targets. Poulsen C, Akhter Y, Jeon AH, Schmitt-Ulms G, Meyer HE, Stefanski A, Stühler K, Wilmanns M, Song YH. Mol Syst Biol. 2010 Jul 13;6:386. [ PMID: 20631680] |
Functional Description | Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity). |
Sequence Annotation | ACT_SITE 342 342 Proton acceptor (By similarity).
ACT_SITE 343 343 Proton acceptor (By similarity).
METAL 273 273 Zinc (By similarity).
METAL 276 276 Zinc (By similarity).
METAL 376 376 Zinc (By similarity).
METAL 435 435 Zinc (By similarity).
BINDING 136 136 NAD (By similarity).
BINDING 200 200 NAD (By similarity).
BINDING 228 228 NAD (By similarity).
BINDING 251 251 Substrate (By similarity).
BINDING 273 273 Substrate (By similarity).
BINDING 276 276 Substrate (By similarity).
BINDING 343 343 Substrate (By similarity).
BINDING 376 376 Substrate (By similarity).
BINDING 430 430 Substrate (By similarity).
BINDING 435 435 Substrate (By similarity). |
Keyword | Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 445 AA |
Protein Sequence | MNMMAKFQMS RIDLRNRVLS AAQLRSALPR GGVDVDAVVP KVRPIVDAVA QRGAQAALEY 60
GESFDGIRPE TVRVPRELLS QALENLDADV RAALQVSIDR ARAVHADQRR TDTTTTLAPG 120
ATVTERWVPV ERVGLYVPGG NAVYPSSVVM NVVPAQTAGV DSMVIASPPQ GQFGGRPHPT 180
ILAAAALLGV DEVWAVGGAQ AVALLAYGGT DTDGAELAPV DMITGPGNIY VTAAKRICRS 240
QVGIDAEAGP TEIAILADHT ADPVHVAADL ISQAEHDEMA ASVLVTDSET LAEATDRELA 300
NQLATTKHVE RVTAALSGKQ SAIVLVDDID AGVRTVNAYA AEHLEIQTVD APGVAGRIRS 360
AGAIFVGAWS PVSLGDYCAG SNHVLPTAGC ARHSSGLSVQ TFLRGIHVVE YDEAALKDVS 420
GHVITLSKAE DLPAHGEAVR RRFER 445 |
Gene Ontology | GO:0004399; F:histidinol dehydrogenase activity; IEA:HAMAP. GO:0051287; F:NAD binding; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:HAMAP. GO:0000105; P:histidine biosynthetic process; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |