CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044280
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histone H1t 
Protein Synonyms/Alias
 Histone cluster 1, H1t 
Gene Name
 Hist1h1t 
Gene Synonyms/Alias
 RP23-283N14.20-001 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
67MSLAALKKALAAAGYacetylation[1]
67MSLAALKKALAAAGYsuccinylation[1]
67MSLAALKKALAAAGYubiquitination[2]
78AAGYDVEKNNSRIKLacetylation[1, 3, 4]
78AAGYDVEKNNSRIKLsuccinylation[1]
78AAGYDVEKNNSRIKLubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Chromosome; Complete proteome; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 209 AA 
Protein Sequence
MSETAPAASS TLVPAPVEEK PSSKRRGKKP GLAPARKPRG FSVSKLIPEA LSTSQERAGM 60
SLAALKKALA AAGYDVEKNN SRIKLALKRL VNKGVLVQTK GTGASGSFKL SKKAASGNDK 120
GKGKKSASAK AKKMGLPRAS RSPKSSKTKA VKKPKATPTK ASGSGRKTKG AKGVQQRKSP 180
AKARAANPNS GKAKMVMQKT DLRKAAGRK 209 
Gene Ontology
 GO:0000794; C:condensed nuclear chromosome; IDA:MGI.
 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0007339; P:binding of sperm to zona pellucida; IGI:MGI.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0030317; P:sperm motility; IGI:MGI.
 GO:0007283; P:spermatogenesis; IGI:MGI. 
Interpro
 IPR005818; Histone_H1/H5.
 IPR005819; Histone_H5.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00538; Linker_histone 
SMART
 SM00526; H15 
PROSITE
 PS51504; H15 
PRINTS
 PR00624; HISTONEH5.