UniProt Accession

 RL4_ECOLI; P60723; P02388; Q2M6Y4 

Genbank Protein ID

 X02613; U18997; U00096; AP009048 

Genbank Nucleotide ID

 CAA26461.1; AAA58116.1; AAC76344.1; BAE77972.1 

Protein Name

 50S ribosomal protein L4 

Protein Synonyms/Alias

  

Gene Name

 rplD 

Gene Synonyms/Alias

 eryA; b3319; JW3281 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
74	RARSGSIKSPIWRSG	acetylation	[1]
106	KMYRGALKSILSELV	acetylation	[1, 2]
123	DRLIVVEKFSVEAPK	acetylation	[1, 3]
132	SVEAPKTKLLAQKLK	acetylation	[1]
137	KTKLLAQKLKDMALE	acetylation	[1, 3]
166	LAARNLHKVDVRDAT	acetylation	[1]
185	VSLIAFDKVVMTADA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [3] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508] 

Functional Description

 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. 

Sequence Annotation

  

Keyword

 3D-structure; Antibiotic resistance; Complete proteome; Direct protein sequencing; Reference proteome; Repressor; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding; Transcription; Transcription regulation; Transcription termination; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0019843; F:rRNA binding; IEA:HAMAP.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0030371; F:translation repressor activity; IDA:EcoliWiki.
 GO:0006353; P:DNA-dependent transcription, termination; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR002136; Ribosomal_L4/L1e.
 IPR013005; Ribosomal_L4/L1e_bac-type.
 IPR023574; Ribosomal_L4_dom. 

Pfam

 PF00573; Ribosomal_L4 

SMART

  

PROSITE

  

PRINTS