CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023876
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 42 
Protein Synonyms/Alias
  
Gene Name
 LRRC42 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
40GVRSSLQKPRPFRLFubiquitination[1, 2]
66REDDTARKEKTDHFIubiquitination[2]
68DDTARKEKTDHFIFTubiquitination[2]
127SAAEARQKFTEPGAGubiquitination[2, 3]
140AGLRALQKFTEAYGSubiquitination[2]
165RYLVISEKLEEIKSFubiquitination[2, 3]
170SEKLEEIKSFRELTCubiquitination[2, 3]
209SVTQLHLKDNCLSDAubiquitination[2]
220LSDAGVRKMTAPVRVubiquitination[2]
259GYLFSFRKLNCLDISubiquitination[2]
271DISGTGLKDIKTVKHubiquitination[2, 4, 5]
274GTGLKDIKTVKHKLQubiquitination[2]
290HIGLVHSKVPLKEFDubiquitination[2, 3, 4]
294VHSKVPLKEFDHSNCubiquitination[2, 4]
302EFDHSNCKTEGWADQubiquitination[2]
323RVTAEAVKPRETSEPubiquitination[2, 3]
349SRAEAPLKCPLADTHubiquitination[2, 4]
367SEKLQFYKEKAPDCHubiquitination[2]
369KLQFYKEKAPDCHGPubiquitination[2]
389AISSQESKKSKKRPFubiquitination[3]
393QESKKSKKRPFEESEubiquitination[2, 3]
411NNSSQPSKQKYVCLAubiquitination[3, 4]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 REPEAT 149 170 LRR 1.
 REPEAT 174 195 LRR 2.
 REPEAT 202 222 LRR 3.
 REPEAT 234 255 LRR 4.
 REPEAT 259 280 LRR 5.
 MOD_RES 407 407 Phosphoserine.  
Keyword
 Complete proteome; Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 428 AA 
Protein Sequence
MSYYLSSENH LDPGPIYMRE NGQLHMVNLA LDGVRSSLQK PRPFRLFPKG FSVELCMNRE 60
DDTARKEKTD HFIFTYTREG NLRYSAKSLF SLVLGFISDN VDHIDSLIGF PEQIAEKLFS 120
AAEARQKFTE PGAGLRALQK FTEAYGSLVL CSLCLRNRYL VISEKLEEIK SFRELTCLDL 180
SCCKLGDEHE LLEHLTNEAL SSVTQLHLKD NCLSDAGVRK MTAPVRVMKR GLENLTLLDL 240
SCNPEITDAG IGYLFSFRKL NCLDISGTGL KDIKTVKHKL QTHIGLVHSK VPLKEFDHSN 300
CKTEGWADQI VLQWERVTAE AVKPRETSEP RAAAQRFYGK RSRAEAPLKC PLADTHMNSS 360
EKLQFYKEKA PDCHGPVLKH EAISSQESKK SKKRPFEESE TEQNNSSQPS KQKYVCLAVE 420
DWDLLNSY 428 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS