CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042587
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Wolframin 
Protein Synonyms/Alias
  
Gene Name
 WFS1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
130DDFVEITKKYAKGVIubiquitination[1]
134EITKKYAKGVIPSSLubiquitination[1, 2, 3]
155DDDELAGKSPEDLPLubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 252 AA 
Protein Sequence
XQGRREAVKL LRRCLADRRG ITSENEREVR QLSSETDLER AVRKAALVMY WKLNPKKKKQ 60
VAVAELLENV GQVNEHDGGA QPGPVPKSLQ KQRRMLERLV SSELWGAHAV FSHASAKNYI 120
ALDDFVEITK KYAKGVIPSS LFLQDDEDDD ELAGKSPEDL PLRLKVVKYP LHAIMEIKEY 180
LIDMASRAGM HWLSTIIPTH HINALIFFFI VSNLTIDFFA FFIPLVIFYL SFISMVICTL 240
KVFQDSKAWE NF 252 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
 GO:0055074; P:calcium ion homeostasis; IEA:InterPro. 
Interpro
 IPR026208; Wolframin.
 IPR026209; Wolframin_fam. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR02060; WOLFFAMILY.
 PR02061; WOLFRAMIN.