UniProt Accession

 WIPI1_MOUSE; Q8R3E3; Q8BGE1; Q8R1A9; Q8R1C7 

Genbank Protein ID

 AK031672; AK034907; AK050495; AK159608; AK170563; BC024811; BC024883; BC025560 

Genbank Nucleotide ID

 BAC27504.1; BAC28878.1; BAE20673.1; BAE35227.1; BAE41884.1; AAH24811.1; AAH24883.1; AAH25560.1 

Protein Name

 WD repeat domain phosphoinositide-interacting protein 1 

Protein Synonyms/Alias

 WIPI-1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WIPI 49 kDa 

Gene Name

 Wipi1 

Gene Synonyms/Alias

 D11Ertd498e 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
325	CTLSTIQKLPRLLVA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. 

Sequence Annotation

 REPEAT 184 224 WD 1.
 REPEAT 230 269 WD 2.
 REPEAT 312 351 WD 3.
 MOTIF 131 136 Nuclear receptor interaction (By  

Keyword

 Alternative splicing; Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Direct protein sequencing; Endosome; Golgi apparatus; Membrane; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 446 AA 

Protein Sequence

Gene Ontology

 GO:0000421; C:autophagic vacuole membrane; IBA:RefGenome.
 GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0010008; C:endosome membrane; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0034045; C:pre-autophagosomal structure membrane; IBA:RefGenome.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0050681; F:androgen receptor binding; IBA:RefGenome.
 GO:0030331; F:estrogen receptor binding; IBA:RefGenome.
 GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IBA:RefGenome.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:RefGenome.
 GO:0000045; P:autophagic vacuole assembly; IBA:RefGenome.
 GO:0048203; P:vesicle targeting, trans-Golgi to endosome; IEA:Compara. 

Interpro

 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS