UniProt Accession

 TNNC2_MOUSE; P20801 

Genbank Protein ID

 M57590; BC024390 

Genbank Nucleotide ID

 AAA37642.1; AAH24390.1 

Protein Name

 Troponin C, skeletal muscle 

Protein Synonyms/Alias

 STNC 

Gene Name

 Tnnc2 

Gene Synonyms/Alias

 Tncs 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
38	GGGDISVKELGTVMR	ubiquitination	[1]
89	RQMKEDAKGKSEEEL	ubiquitination	[1]
91	MKEDAKGKSEEELAE	ubiquitination	[1]
137	EEIESLMKDGDKNND	ubiquitination	[1]
141	SLMKDGDKNNDGRID	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. 

Sequence Annotation

 DOMAIN 15 50 EF-hand 1.
 DOMAIN 51 86 EF-hand 2.
 DOMAIN 91 126 EF-hand 3.
 DOMAIN 127 160 EF-hand 4.
 MOD_RES 2 2 N-acetylthreonine (By similarity).  

Keyword

 Acetylation; Calcium; Complete proteome; Metal-binding; Muscle protein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 160 AA 

Protein Sequence

Gene Ontology

 GO:0005861; C:troponin complex; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0003009; P:skeletal muscle contraction; IEA:Compara. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS