| Tag | Content |
|---|
| CPLM ID | CPLM-021608 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | POZ-, AT hook-, and zinc finger-containing protein 1 |
Protein Synonyms/Alias | BTB/POZ domain zinc finger transcription factor; Protein kinase A RI subunit alpha-associated protein; Zinc finger and BTB domain-containing protein 19; Zinc finger protein 278; Zinc finger sarcoma gene protein |
Gene Name | PATZ1 |
Gene Synonyms/Alias | PATZ; RIAZ; ZBTB19; ZNF278; ZSG |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 157 | EICQEVIKQSNVQIL | ubiquitination | [1] | | 272 | RGRGRPRKANLLDSM | ubiquitination | [1, 2] | | 299 | LPCGLCGKVFTDANR | ubiquitination | [1, 2] | | 353 | RKRSRTRKQVACEIC | ubiquitination | [1] | | 596 | DMAVPKNKMESDGEK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] [2] Integrated proteomic analysis of post-translational modifications by serial enrichment. Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods. 2013 Jul;10(7):634-7. [ PMID: 23749302] |
Functional Description | Transcriptional repressor. |
Sequence Annotation | DOMAIN 41 130 BTB.
DNA_BIND 264 276 A.T hook.
ZN_FING 292 314 C2H2-type 1.
ZN_FING 355 377 C2H2-type 2.
ZN_FING 383 405 C2H2-type 3.
ZN_FING 413 436 C2H2-type 4.
ZN_FING 442 464 C2H2-type 5.
ZN_FING 495 518 C2H2-type 6.
ZN_FING 605 628 C2H2-type 7.
MOD_RES 282 282 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 687 AA |
Protein Sequence | MERVNDASCG PSGCYTYQVS RHSTEMLHNL NQQRKNGGRF CDVLLRVGDE SFPAHRAVLA 60
ACSEYFESVF SAQLGDGGAA DGGPADVGGA TAAPGGGAGG SRELEMHTIS SKVFGDILDF 120
AYTSRIVVRL ESFPELMTAA KFLLMRSVIE ICQEVIKQSN VQILVPPARA DIMLFRPPGT 180
SDLGFPLDMT NGAALAANSN GIAGSMQPEE EAARAAGAAI AGQASLPVLP GVDRLPMVAG 240
PLSPQLLTSP FPSVASSAPP LTGKRGRGRP RKANLLDSMF GSPGGLREAG ILPCGLCGKV 300
FTDANRLRQH EAQHGVTSLQ LGYIDLPPPR LGENGLPISE DPDGPRKRSR TRKQVACEIC 360
GKIFRDVYHL NRHKLSHSGE KPYSCPVCGL RFKRKDRMSY HVRSHDGSVG KPYICQSCGK 420
GFSRPDHLNG HIKQVHTSER PHKCQTCNAS FATRDRLRSH LACHEDKVPC QVCGKYLRAA 480
YMADHLKKHS EGPSNFCSIC NRGFSSASYL KVHVKTHHGV PLPQVSRHQE PILNGGAAFH 540
CARTYGNKEG QKCSHQDPIE SSDSYGDLSD ASDLKTPEKQ SANGSFSCDM AVPKNKMESD 600
GEKKYPCPEC GSFFRSKSYL NKHIQKVHVR ALGGPLGDLG PALGSPFSPQ QNMSLLESFG 660
FQIVQSAFAS SLVDPEVDQQ PMGPEGK 687 |
Gene Ontology | GO:0005634; C:nucleus; TAS:UniProtKB. GO:0003682; F:chromatin binding; IEA:Compara. GO:0003677; F:DNA binding; NAS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0008584; P:male gonad development; IEA:Compara. GO:0045892; P:negative regulation of transcription, DNA-dependent; TAS:UniProtKB. GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara. GO:0007283; P:spermatogenesis; IEA:Compara. GO:0030217; P:T cell differentiation; IEA:Compara. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |