CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033810
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pyrroline-5-carboxylate reductase 
Protein Synonyms/Alias
  
Gene Name
 PYCRL 
Gene Synonyms/Alias
 hCG_32057 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
230QTLLGTAKMLLHEGQubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 286 AA 
Protein Sequence
MGGERSGVRG NKMAAAEPSP RRVGFVGAGR MAGAIAQGLI RAGKVEAQHI LASAPTDRNL 60
CHFQALGCRT THSNQEVLQS CLLVIFATKP HVLPAVLAEV APVVTTEHIL VSVAAGVSLS 120
TLEELLPPNT RVLRVLPNLP CVVQEGAIVM ARGRHVGSSE TNLLQHLLEA CGRCEEVPEA 180
YVDIHTGLSG SGVAFVCAFS EALAEGAVKM GMPSSLAHRI AAQTLLGTAK MLLHEGQHPA 240
QLRSDVCTPG GTTIYGLHAL EQGGLRAATM SAVEAATCRA KELSRK 286 
Gene Ontology
 GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
 GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR016040; NAD(P)-bd_dom.
 IPR004455; NADP_OxRdtase_F420.
 IPR000304; Pyrroline-COOH_reductase. 
Pfam
 PF03807; F420_oxidored 
SMART
  
PROSITE
 PS00521; P5CR 
PRINTS