UniProt Accession

 ATPF_YEAST; P05626; D6W3T8; E9P905; Q02830 

Genbank Protein ID

 X06732; X16721; U41849; AY692976; BK006949 

Genbank Nucleotide ID

 CAA29909.1; CAA34703.1; AAB68260.1; AAT92995.1; DAA11354.1 

Protein Name

 ATP synthase subunit 4, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 ATP4 

Gene Synonyms/Alias

 YPL078C; LPF7C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
139	NKHVEAVKDRIDSVS	acetylation	[1]
223	QSELGNPKFQEKVLQ	acetylation	[1]
223	QSELGNPKFQEKVLQ	ubiquitination	[2]
227	GNPKFQEKVLQQSIS	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. 

Sequence Annotation

 MOD_RES 144 144 Phosphoserine.  

Keyword

 CF(0); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0000274; C:mitochondrial proton-transporting ATP synthase, stator stalk; IDA:SGD.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0015986; P:ATP synthesis coupled proton transport; IDA:SGD.
 GO:0035786; P:protein complex oligomerization; IMP:SGD. 

Interpro

 IPR008688; ATPase_B_chain/sub_B/MI25.
 IPR013837; ATPase_F0_sub_B/B_chain. 

Pfam

 PF05405; Mt_ATP-synt_B 

SMART

  

PROSITE

  

PRINTS