UniProt Accession

 PDXY_ECOLI; P77150 

Genbank Protein ID

 U00096; AP009048 

Genbank Nucleotide ID

 AAC74708.1; BAA15397.1 

Protein Name

 Pyridoxamine kinase 

Protein Synonyms/Alias

 PM kinase 

Gene Name

 pdxY 

Gene Synonyms/Alias

 ydgS; b1636; JW1628 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
286	EHYFSATKL******	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine, but has negligible activity toward pyridoxal and pyridoxine as substrates. 

Sequence Annotation

 NP_BIND 182 183 ATP (By similarity).
 NP_BIND 208 223 ATP (By similarity).
 BINDING 10 10 Substrate (By similarity).
 BINDING 45 45 Substrate (By similarity).
 BINDING 224 224 Substrate (By similarity).  

Keyword

 3D-structure; ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Transferase; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 287 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0004340; F:glucokinase activity; IEA:HAMAP.
 GO:0008478; F:pyridoxal kinase activity; IDA:EcoliWiki.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0051156; P:glucose 6-phosphate metabolic process; IEA:GOC.
 GO:0006096; P:glycolysis; IEA:HAMAP.
 GO:0009443; P:pyridoxal 5'-phosphate salvage; IMP:EcoliWiki.
 GO:0042817; P:pyridoxal metabolic process; IMP:EcoliWiki.
 GO:0042819; P:vitamin B6 biosynthetic process; IMP:EcoliWiki. 

Interpro

 IPR013749; HMP-P_kinase-1.
 IPR004625; PyrdxlP_synth_PyrdxlKinase.
 IPR023685; Pyridoxal_kinase_PdxY. 

Pfam

 PF08543; Phos_pyr_kin 

SMART

  

PROSITE

  

PRINTS