CPLM-044245

Genbank Nucleotide ID

Platelet-activating factor acetylhydrolase IB subunit alpha

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
33	EAYSVFKKEAELDVN	ubiquitination	[1, 2, 3]
46	VNEELDKKYAGLLEK	ubiquitination	[2]
53	KYAGLLEKKWTSVIR	acetylation	[3, 4]
54	YAGLLEKKWTSVIRL	ubiquitination	[2]
71	KVMELESKLNEAKEE	acetylation	[5]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
[4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
[5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]

Functional Description

Complete proteome; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0031252; C:cell leading edge; IEA:Compara.
GO:0005813; C:centrosome; IEA:Compara.
GO:0005829; C:cytosol; IEA:Compara.
GO:0030426; C:growth cone; IEA:Compara.
GO:0005871; C:kinesin complex; IEA:Compara.
GO:0031512; C:motile primary cilium; IEA:Compara.
GO:0043025; C:neuronal cell body; IEA:Compara.
GO:0005635; C:nuclear envelope; IEA:Compara.
GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
GO:0031982; C:vesicle; IEA:Compara.
GO:0001675; P:acrosome assembly; IEA:Compara.
GO:0030036; P:actin cytoskeleton organization; IEA:Compara.
GO:0008344; P:adult locomotory behavior; IEA:Compara.
GO:0001667; P:ameboidal cell migration; IEA:Compara.
GO:0021895; P:cerebral cortex neuron differentiation; IEA:Compara.
GO:0051660; P:establishment of centrosome localization; IEA:Compara.
GO:0021766; P:hippocampus development; IEA:Compara.
GO:0021819; P:layer formation in cerebral cortex; IEA:Compara.
GO:0007611; P:learning or memory; IEA:Compara.
GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara.
GO:0046329; P:negative regulation of JNK cascade; IEA:Compara.
GO:0010977; P:negative regulation of neuron projection development; IEA:Compara.
GO:0007405; P:neuroblast proliferation; IEA:Compara.
GO:0050885; P:neuromuscular process controlling balance; IEA:Compara.
GO:0001764; P:neuron migration; IEA:Compara.
GO:0051081; P:nuclear envelope disassembly; IEA:Compara.
GO:0007097; P:nuclear migration; IEA:Compara.
GO:0036035; P:osteoclast development; IEA:Compara.
GO:0045773; P:positive regulation of axon extension; IEA:Compara.
GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IEA:Compara.
GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
GO:0009306; P:protein secretion; IEA:Compara.
GO:0032319; P:regulation of Rho GTPase activity; IEA:Compara.
GO:0008090; P:retrograde axon cargo transport; IEA:Compara.
GO:0017145; P:stem cell division; IEA:Compara.
GO:0007268; P:synaptic transmission; IEA:Compara.
GO:0047496; P:vesicle transport along microtubule; IEA:Compara.

IPR017252; Dynein_regulator_LIS1.
IPR006594; LisH_dimerisation.
IPR013720; LisH_dimerisation_subgr.