UniProt Accession

 TIM16_YEAST; P42949; D6VW80; Q6B2X3 

Genbank Protein ID

 X85021; Z49379; AY692607; BK006943 

Genbank Nucleotide ID

 CAA59390.1; CAA89399.1; AAT92626.1; DAA08696.1 

Protein Name

 Mitochondrial import inner membrane translocase subunit TIM16 

Protein Synonyms/Alias

 Presequence translocated-associated motor subunit PAM16 

Gene Name

 PAM16 

Gene Synonyms/Alias

 TIM16; YJL104W; J0822 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
75	KGDLNMDKINNRFNY	acetylation	[1]
89	YLFEVNDKEKGGSFY	acetylation	[1]
109	YRAAERLKWELAQRE	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation. 

Sequence Annotation

 REGION 57 113 J-like.  

Keyword

 3D-structure; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0001405; C:presequence translocase-associated import motor; IDA:SGD.
 GO:0019904; F:protein domain specific binding; IDA:SGD.
 GO:0030150; P:protein import into mitochondrial matrix; IPI:SGD. 

Interpro

 IPR005341; Tim16. 

Pfam

  

SMART

  

PROSITE

  

PRINTS