CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030940
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exosome component 10 
Protein Synonyms/Alias
 cDNA FLJ60634, highly similar to Exosome component 10 
Gene Name
 EXOSC10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
136DEASGVNKNQQPVLPubiquitination[1, 2]
150PAGLQVPKTVVSSWNubiquitination[2]
186NIIRPQLKFREKIDNubiquitination[2]
210FIKPNAQKPLPQALSubiquitination[2]
417YCNVDSNKQYQLADWubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 679 AA 
Protein Sequence
MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS GGLPQFGDEY 60
DFYRSFPGFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR SKVTELEDKF DLLVDANDVI 120
LERVGILLDE ASGVNKNQQP VLPAGLQVPK TVVSSWNRKA AEYGKKAKSE TFRLLHAKNI 180
IRPQLKFREK IDNSNTPFLP KIFIKPNAQK PLPQALSKER RERPQDRPED LDVPPALADF 240
IHQQRTQQVE QDMFAHPYQY ELNHFTPADA VLQKPQPQLY RPIEETPCHF ISSLDELVEL 300
NEKLLNCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFII DTLELRSDMY ILNESLTDPA 360
IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLGR HSLDHLLKLY CNVDSNKQYQ 420
LADWRIRPLP EEMLSYARDD THYLLYIYDK MRLEMWERGN GQPVQLQVVW QRSRDICLKK 480
FIKPIFTDES YLELYRKQKK HLNTQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI 540
AEELPKEPQG IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSEVAAGV KKSGPLPSAE 600
VECRICFLPQ EGKRQVTASA STPLTEACAD SWQKATAGLH VLHASLLVSF NAEIGECSLW 660
TSRLLPCPSG WLSNHPNQW 679 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006396; P:RNA processing; IEA:InterPro. 
Interpro
 IPR002562; 3'-5'_exonuclease_dom.
 IPR012588; Exosome-assoc_fac_Rrp6_N.
 IPR010997; HRDC-like.
 IPR002121; HRDC_dom.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF01612; DNA_pol_A_exo1
 PF00570; HRDC
 PF08066; PMC2NT 
SMART
 SM00474; 35EXOc
 SM00341; HRDC 
PROSITE
 PS50967; HRDC 
PRINTS