UniProt Accession

 SLX5_YEAST; P32828; D6VRX6 

Genbank Protein ID

 L07745; Z48432; Z74061; BK006938 

Genbank Nucleotide ID

 AAA34671.1; CAA88346.1; CAA98570.1; DAA11836.1 

Protein Name

 E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 

Protein Synonyms/Alias

 Hexose metabolism-related protein HEX3; Synthetic lethal of unknown function protein 5 

Gene Name

 SLX5 

Gene Synonyms/Alias

 HEX3; YDL013W; D2875 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
430	RERDVVMKNLMNKTR	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Mediates ubiquitination and susbsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Promotes UBC4-dependent ubiquitination that mediates the proteolytic down-regulation of sumoylated proteins. Involved in the stimulation of ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Has a role in localizing the DNA damage protein DCD2. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression. Along with SIR2, promotes silencing of genes at telomeric or ribosomal DNA (rDNA) loci. 

Sequence Annotation

 MOD_RES 14 14 Phosphoserine.
 MOD_RES 29 29 Phosphoserine.  

Keyword

 Complete proteome; DNA damage; DNA repair; Ligase; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 619 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0000151; C:ubiquitin ligase complex; IDA:SGD.
 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0032183; F:SUMO binding; IDA:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0016925; P:protein sumoylation; IMP:SGD.
 GO:0016567; P:protein ubiquitination; IDA:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006974; P:response to DNA damage stimulus; IMP:SGD.
 GO:0000723; P:telomere maintenance; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001841; Znf_RING. 

Pfam

  

SMART

 SM00184; RING 

PROSITE

  

PRINTS