UniProt Accession

 C4BPA_MOUSE; P08607; Q91X48 

Genbank Protein ID

 M17122; AK149468; AK149477; CH466520; BC012257 

Genbank Nucleotide ID

 AAA37312.1; BAE28899.1; BAE28904.1; EDL39738.1; AAH12257.1 

Protein Name

 C4b-binding protein 

Protein Synonyms/Alias

 C4bp 

Gene Name

 C4bpa 

Gene Synonyms/Alias

 C4bp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
165	SSCEVRGKGVAWSNP	ubiquitination	[1]
331	LVTYECDKGYRLVGK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. 

Sequence Annotation

 DOMAIN 57 117 Sushi 1.
 DOMAIN 118 178 Sushi 2.
 DOMAIN 179 242 Sushi 3.
 DOMAIN 243 301 Sushi 4.
 DOMAIN 302 357 Sushi 5.
 DOMAIN 358 415 Sushi 6.
 CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 275 275 N-linked (GlcNAc...).
 CARBOHYD 292 292 N-linked (GlcNAc...) (Potential).
 CARBOHYD 366 366 N-linked (GlcNAc...) (Potential).
 CARBOHYD 381 381 N-linked (GlcNAc...) (Potential).
 CARBOHYD 428 428 N-linked (GlcNAc...) (Potential).
 DISULFID 58 103 By similarity.
 DISULFID 88 115 By similarity.
 DISULFID 120 160 By similarity.
 DISULFID 146 176 By similarity.
 DISULFID 181 223 By similarity.
 DISULFID 209 240 By similarity.
 DISULFID 245 287 By similarity.
 DISULFID 273 299 By similarity.
 DISULFID 303 343 By similarity.
 DISULFID 329 355 By similarity.
 DISULFID 359 400 By similarity.
 DISULFID 386 413 By similarity.  

Keyword

 Complement pathway; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Innate immunity; Reference proteome; Repeat; Secreted; Signal; Sushi. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW. 

Interpro

 IPR000436; Sushi_SCR_CCP. 

Pfam

 PF00084; Sushi 

SMART

 SM00032; CCP 

PROSITE

 PS50923; SUSHI 

PRINTS