CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020797
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein RUFY3 
Protein Synonyms/Alias
 Rap2-interacting protein x; RIPx; Single axon-regulated protein; Singar 
Gene Name
 Rufy3 
Gene Synonyms/Alias
 D5Bwg0860e; Ripx 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
77MNLMNMAKLSIKGLIubiquitination[1]
157VKDLPGLKTPVGRGRubiquitination[1]
264ITAILDQKNYVEELNubiquitination[1]
294LLEKSNTKLTEELAVubiquitination[1]
350SEARKHLKEETQLRLubiquitination[1]
382LAMKMLEKDVCEKQDubiquitination[1]
387LEKDVCEKQDALVSLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). 
Sequence Annotation
 DOMAIN 95 227 RUN.  
Keyword
 3D-structure; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Developmental protein; Differentiation; Neurogenesis; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 469 AA 
Protein Sequence
MSALTPPTDM PTPTTDKITQ AAMETIYLCK FRVSMDGEWL CLRELDDISL TPDPEPTHED 60
PNYLMANERM NLMNMAKLSI KGLIESALNL GRTLDSDYAP LQQFFVVMEH CLKHGLKAKK 120
TFLGQNKSFW GPLELVEKLV PEAAEITASV KDLPGLKTPV GRGRAWLRLA LMQKKLSEYM 180
KALINKKELL SEFYEVNALM MEEEGAIIAG LLVGLNVIDA NFCMKGEDLD SQVGVIDFSM 240
YLKDGNSSKG SEGDGQITAI LDQKNYVEEL NRHLNATVNN LQTKVDLLEK SNTKLTEELA 300
VANNRIITLQ EEMERVKEES SYLLESNRKG PKQDRTAEGQ ALSEARKHLK EETQLRLDVE 360
KELELQISMR QEMELAMKML EKDVCEKQDA LVSLRQQLDD LRALKHELAF KLQSSDLGVK 420
QKSELNSRLE EKTNQMAATI KQLEQSEKDL VKQAKTLNSA ANKLIPKHH 469 
Gene Ontology
 GO:0030175; C:filopodium; IEA:Compara.
 GO:0030426; C:growth cone; IEA:Compara.
 GO:0050771; P:negative regulation of axonogenesis; IEA:Compara. 
Interpro
 IPR004012; Run. 
Pfam
 PF02759; RUN 
SMART
 SM00593; RUN 
PROSITE
 PS50826; RUN 
PRINTS