| Tag | Content |
|---|
| CPLM ID | CPLM-001428 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily KQT member 3 |
Protein Synonyms/Alias | KQT-like 3; Potassium channel subunit alpha KvLQT3; Voltage-gated potassium channel subunit Kv7.3 |
Gene Name | Kcnq3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 424 | LEAAASQKLGLLDRV | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Probably important in the regulation of neuronal excitability. Associates with KCNQ2 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. |
Sequence Annotation | MOTIF 317 322 Selectivity filter (By similarity).
MOD_RES 34 34 Phosphoserine (By similarity).
MOD_RES 599 599 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Ion channel; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 873 AA |
Protein Sequence | MGLKARRAAG AAGGGGGEGG GGGGGAANPA GGDSAVAGDE ERKVGLAPGD VEQVTLALGT 60
GADKDGTLLL EGGGREEGQR RTPQGIGLLA KTPLSRPVKR NNAKYRRIQT LIYDALERPR 120
GWALLYHALV FLIVLGCLIL AVLTTFKEYE TVSGDWLLLL ETFAIFIFGA EFALRIWAAG 180
CCCRYKGWRG RLKFARKPLC MLDIFVLIAS VPVVAVGNQG NVLATSLRSL RFLQILRMLR 240
MDRRGGTWKL LGSAICAHSK ELITAWYIGF LTLILSSFLV YLVEKDVPEM DAQGEEMKEE 300
FETYADALWW GLITLATIGY GDKTPKTWEG RLIAATFSLI GVSFFALPAG ILGSGLALKV 360
QEQHRQKHFE KRRKPAAELI QAAWRYYATN PNRLDLVATW RFYESVVSFP FFRKEQLEAA 420
ASQKLGLLDR VRLSNPRGSN TKGKLFTPLN VDAIEESPSK EPKPVGLNNK ERFRTAFRMK 480
AYAFWQSSED AGTGDPMTED RGYGNDFLIE DMIPTLKAAI RAVRILQFRL YKKKFKETLR 540
PYDVKDVIEQ YSAGHLDMLS RIKYLQTRID MIFTPGPPST PKHKKSQKGS AFTYPSQQSP 600
RNEPYVARAA TSETEDQSMM GKFVKVERQV HDMGKKLDFL VDMHMQHMER LQVHVTEYYP 660
TKGASSPAEG EKKEDNRYSD LKTIICNYSE SGPPDPPYSF HQVPIDRVGP YGFFAHDPVK 720
LTRGGPSSTK AQANLPSSGS TYAERPTVLP ILTLLDSCVS YHSQTELQGP YSDHISPRQR 780
RSITRDSDTP LSLMSVNHEE LERSPSGFSI SQDRDDYVFG PSGGSSWMRE KRYLAEGETD 840
TDTDPFTPSG SMPMSSTGDG ISDSIWTPSN KPT 873 |
Gene Ontology | GO:0043194; C:axon initial segment; IEA:Compara. GO:0033268; C:node of Ranvier; IEA:Compara. GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome. GO:0060081; P:membrane hyperpolarization; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |