| Tag | Content |
|---|
| CPLM ID | CPLM-019522 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Type I inositol 3,4-bisphosphate 4-phosphatase |
Protein Synonyms/Alias | Inositol polyphosphate 4-phosphatase type I |
Gene Name | INPP4A |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 123 | KLSVYDVKDRSQGTM | ubiquitination | [1] | | 222 | LRKDTLLKSVFGGAI | ubiquitination | [1] | | 371 | AAHCQGFKSGGLRKK | ubiquitination | [1] | | 387 | HKFEETKKHTSSGCQ | ubiquitination | [1] | | 407 | PQDVVRAKEIIAQIN | ubiquitination | [1] | | 449 | TLAILADKTRQLVTV | ubiquitination | [1] | | 460 | LVTVCDCKLLANSIH | ubiquitination | [1] | | 546 | RVDKLLQKERLHGEG | ubiquitination | [1] | | 567 | CAGSCTSKKGNPDSH | ubiquitination | [1] | | 568 | AGSCTSKKGNPDSHA | ubiquitination | [1] | | 969 | PPEGTYGKVET**** | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate. |
Sequence Annotation | DOMAIN 31 137 C2.
MOD_RES 355 355 Phosphotyrosine.
MOD_RES 487 487 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Hydrolase; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 977 AA |
Protein Sequence | MTAREHSPRH GARARAMQRA STIDVAADML GLSLAGNIQD PDEPILEFSL ACSELHTPSL 60
DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS IAFFQDSLIN QMTQVKLSVY 120
DVKDRSQGTM YLLGSGTFIV KDLLQDRHHR LHLTLRSAES DRVGNITVIG WQMEEKSDQR 180
PPVTRSVDTV NGRMVLPVDE SLTEALGIRS KYASLRKDTL LKSVFGGAIC RMYRFPTTDG 240
NHLRILEQMA ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT 300
IILTYQENLT DLHQYRGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG SDQNYDIVTI 360
GAPAAHCQGF KSGGLRKKLH KFEETKKHTS SGCQSIIYIP QDVVRAKEII AQINTLKTQV 420
SYYAERLSRA AKDRSATGLE RTLAILADKT RQLVTVCDCK LLANSIHGLN AARPDYIASK 480
ASPTSTEEEQ VMLRNDQDTL MARWTGRNSR SSLQVDWHEE EWEKVWLNVD KSLECIIQRV 540
DKLLQKERLH GEGCEDVFPC AGSCTSKKGN PDSHAYWIRP EDPFCDVPSS PCPSTMPSTA 600
CHPHLTTHCS PPPEESSPGE WSEALYPLLT TLTDCVAMMS DKAKKAMVFL LMQDSAPTIA 660
TYLSLQYRRD VVFCQTLTAL ICGFIIKLRN CLHDDGFLRQ LYTIGLLAQF ESLLSTYGEE 720
LAMLEDMSLG IMDLRNVTFK VTQATSSASA DMLPVITGNR DGFNVRVPLP GPLFDALPRE 780
IQSGMLLRVQ PVLFNVGINE QQTLAERFGD TSLQEVINVE SLVRLNSYFE QFKEVLPEDC 840
LPRSRSQTCL PELLRFLGQN VHARKNKNVD ILWQAAEICR RLNGVRFTSC KSAKDRTAMS 900
VTLEQCLILQ HEHGMAPQVF TQALECMRSE GCRRENTMKN VGSRKYAFNS LQLKAFPKHY 960
RPPEGTYGKV ET 972 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0016316; F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; IEA:EC. GO:0034597; F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity; IEA:EC. GO:0043647; P:inositol phosphate metabolic process; TAS:Reactome. GO:0036092; P:phosphatidylinositol-3-phosphate biosynthetic process; IEA:GOC. GO:0007165; P:signal transduction; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |