| Tag | Content |
|---|
| CPLM ID | CPLM-007770 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform |
Protein Synonyms/Alias | Phosphorylase kinase alpha M subunit |
Gene Name | PHKA1 |
Gene Synonyms/Alias | PHKA |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 435 | RRFSTVPKPDVVVQV | ubiquitination | [1] | | 452 | LAETEEIKTILKDKG | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. |
Sequence Annotation | REGION 810 840 Calmodulin-binding (Potential).
REGION 1046 1086 Calmodulin-binding (Potential).
MOD_RES 200 200 Phosphoserine (By similarity).
MOD_RES 201 201 Phosphoserine (By similarity).
MOD_RES 735 735 Phosphoserine.
MOD_RES 758 758 Phosphoserine.
MOD_RES 972 972 Phosphoserine.
MOD_RES 985 985 Phosphoserine.
MOD_RES 1007 1007 Phosphoserine; by autocatalysis (By
MOD_RES 1018 1018 Phosphoserine; by PKA (By similarity).
MOD_RES 1020 1020 Phosphoserine (By similarity).
MOD_RES 1023 1023 Phosphoserine (By similarity).
LIPID 1220 1220 S-farnesyl cysteine (By similarity). |
Keyword | Alternative splicing; Calmodulin-binding; Carbohydrate metabolism; Cell membrane; Complete proteome; Disease mutation; Glycogen metabolism; Glycogen storage disease; Lipoprotein; Membrane; Muscle protein; Phosphoprotein; Prenylation; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1223 AA |
Protein Sequence | MRSRSNSGVR LDGYARLVQQ TILCHQNPVT GLLPASYDQK DAWVRDNVYS ILAVWGLGLA 60
YRKNADRDED KAKAYELEQS VVKLMRGLLH CMIRQVDKVE SFKYSQSTKD SLHAKYNTKT 120
CATVVGDDQW GHLQLDATSV YLLFLAQMTA SGLHIIHSLD EVNFIQNLVF YIEAAYKTAD 180
FGIWERGDKT NQGISELNAS SVGMAKAALE ALDELDLFGV KGGPQSVIHV LADEVQHCQS 240
ILNSLLPRAS TSKEVDASLL SVVSFPAFAV EDSQLVELTK QEIITKLQGR YGCCRFLRDG 300
YKTPKEDPNR LYYEPAELKL FENIECEWPL FWTYFILDGV FSGNAEQVQE YKEALEAVLI 360
KGKNGVPLLP ELYSVPPDRV DEEYQNPHTV DRVPMGKLPH MWGQSLYILG SLMAEGFLAP 420
GEIDPLNRRF STVPKPDVVV QVSILAETEE IKTILKDKGI YVETIAEVYP IRVQPARILS 480
HIYSSLGCNN RMKLSGRPYR HMGVLGTSKL YDIRKTIFTF TPQFIDQQQF YLALDNKMIV 540
EMLRTDLSYL CSRWRMTGQP TITFPISHSM LDEDGTSLNS SILAALRKMQ DGYFGGARVQ 600
TGKLSEFLTT SCCTHLSFMD PGPEGKLYSE DYDDNYDYLE SGNWMNDYDS TSHARCGDEV 660
ARYLDHLLAH TAPHPKLAPT SQKGGLDRFQ AAVQTTCDLM SLVTKAKELH VQNVHMYLPT 720
KLFQASRPSF NLLDSPHPRQ ENQVPSVRVE IHLPRDQSGE VDFKALVLQL KETSSLQEQA 780
DILYMLYTMK GPDWNTELYN ERSATVRELL TELYGKVGEI RHWGLIRYIS GILRKKVEAL 840
DEACTDLLSH QKHLTVGLPP EPREKTISAP LPYEALTQLI DEASEGDMSI SILTQEIMVY 900
LAMYMRTQPG LFAEMFRLRI GLIIQVMATE LAHSLRCSAE EATEGLMNLS PSAMKNLLHH 960
ILSGKEFGVE RSVRPTDSNV SPAISIHEIG AVGATKTERT GIMQLKSEIK QVEFRRLSIS 1020
AESQSPGTSM TPSSGSFPSA YDQQSSKDSR QGQWQRRRRL DGALNRVPVG FYQKVWKVLQ 1080
KCHGLSVEGF VLPSSTTREM TPGEIKFSVH VESVLNRVPQ PEYRQLLVEA ILVLTMLADI 1140
EIHSIGSIIA VEKIVHIAND LFLQEQKTLG ADDTMLAKDP ASGICTLLYD SAPSGRFGTM 1200
TYLSKAAATY VQEFLPHSIC AMQ 1223 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro. GO:0004689; F:phosphorylase kinase activity; TAS:ProtInc. GO:0006006; P:glucose metabolic process; TAS:Reactome. GO:0005980; P:glycogen catabolic process; TAS:Reactome. GO:0044281; P:small molecule metabolic process; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |