| Tag | Content |
|---|
| CPLM ID | CPLM-023575 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA replication licensing factor Mcm7 |
Protein Synonyms/Alias | Minichromosome maintenance 7 protein; DmMCM3 |
Gene Name | Mcm7 |
Gene Synonyms/Alias | CG4978 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 545 | TYVHSHSKQPPTRVK | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. |
Sequence Annotation | DOMAIN 332 538 MCM.
NP_BIND 381 388 ATP (Potential).
MOTIF 513 516 Arginine finger. |
Keyword | ATP-binding; Cell cycle; Complete proteome; DNA replication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 720 AA |
Protein Sequence | MARRDYAQDR ESIKTFLSEF CKCDDDGKKE FVYGSQLVKL AHREQVLITI DLDDLAEFNE 60
SLAEAVVDNC RRYTSIFSDV IAELLPSYKQ QEVHAKDALD VYIEHRLMME SRTRNPMEQR 120
DERNSFPSEL MKRFEVGFKP LSTEKAHSIR EVKAQHIGKL VTVRGIVTRC TEVKPMMVVA 180
TYTCDRCGSE TYQPVNSLSF TPVHDCPSDD CRVNKAGGRL YLQTRGSKFV KFQEVKMQEH 240
SDQVPVGHIP RSMTIMCRGE VTRMAQPGDH IVVSGVFLPL MRTGFAQMIQ GLLSETFLQA 300
HRIICINKND EISDKDAELT PEELEELAQD DFYERLATSL APEIYGHLDV KKALLLLLVG 360
GVDKRPDGMK IRGNINICLM GDPGVAKSQL LGYISRLAVR SQYTTGRGSS GVGLTAAVMK 420
DPLTGEMTLE GGALVLADQG VCCIDEFDKM ADQDRTAIHE VMEQQTISIA KAGIMTTLNA 480
RVSILAAANP AFGRYNPRRT VEQNIQLPAA LLSRFDLLWL IQDKPDRDND LRLAKHITYV 540
HSHSKQPPTR VKALDMNLMR RYINLCKRKN PTIPDELTDY IVGAYVELRR EARNQKDMTF 600
TSARNLLGIL RLSTALARLR LSDSVEKDDV AEALRLLEMS KDSLNQIHEH QKGHVPNTSD 660
RIFAIVRELA GSGKAVKISD IMDRCTTKGF KPDQVDKCID DYEELNVWQV NMGRTKITFM 720 |
Gene Ontology | |
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