CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034918
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Aldh18a1 
Protein Synonyms/Alias
 Pyrroline-5-carboxylate synthetase (Glutamate gamma-semialdehyde synthetase) (Predicted) 
Gene Name
 Aldh18a1 
Gene Synonyms/Alias
 Pycs_predicted; rCG_57763 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
124SGAVAFGKQRLRHEIacetylation[1]
347ITDIVEGKKVGTFFSacetylation[1]
424RLAGPLLKRLSLSTSacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 795 AA 
Protein Sequence
MLRHVQRSGL QPFSQRLLPW VQSIALPRSH RVQPSAIRHV RSWSNIPFIT VPLSRAHGKP 60
FAHRSELKHA KRIVVKLGSA VVTRGDECGL ALGRLASIVE QVSVLQNQGR EMMLVTSGAV 120
AFGKQRLRHE ILLSQSVRQA LHSGQNHLKE MAIPVLEARA CAAAGQSGLM ALYEAMFTQY 180
SICAAQILVT NLDFHDEQKR RNLNGTLHEL LRMNIVPIVN TNDAVVPPAE PNSDLQGVNV 240
ISVKDNDSLA ARLAVEMKTD LLIVLSDVEG LFDSPPGSDD AKLIDIFYPG DQQSVTFGTK 300
SRVGLGGMEA KVKAALWALQ GGTSVVIANG THPKVSGHVI TDIVEGKKVG TFFSEVKPAG 360
PTVEQQGEMA RSGGRMLATL EPEQRAEIIN HLADLLTDQR EEILLANKKD LEEAEGRLAG 420
PLLKRLSLST SKLNSLAIGL RQIAASSQES VGRVLRRTRI AKNLELEQVT VPIGVLLVIF 480
ESRPDCLPQV AALAIASGNG LLLKGGKEAM HSNRILHLLT QEALSIHGVK EAIQLVNTRE 540
EVEDLCRLDK IIDLIIPRGS SQLVRDIQKA AKGIPVMGHS EGICHMYVDS EASVDKVTRL 600
VRDSKCEYPA ACNALETLLI HRDLLRTPLF DQIIDMLRVE QVKIHAGPKF ASYLTFSPSE 660
VKSLRTEYGD LEVCIEVVDS VQEAIDHIHK YGSSHTDVIV TENEKTAEFF LQHVDSACVF 720
WNASTRFSDG YRFGLGAEVG ISTSRIHARG PVGLEGLLTT KWLLRGQDHV VSDFSEHGRL 780
KYLHENLPVP QRHFS 795 
Gene Ontology
 GO:0004349; F:glutamate 5-kinase activity; IEA:InterPro.
 GO:0004350; F:glutamate-5-semialdehyde dehydrogenase activity; IEA:InterPro.
 GO:0006561; P:proline biosynthetic process; IEA:InterPro. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR001048; Asp/Glu/Uridylate_kinase.
 IPR000965; G-glutamylP_reductase.
 IPR020593; G-glutamylP_reductase_CS.
 IPR001057; Glu/AcGlu_kinase.
 IPR019797; Glutamate_5-kinase_CS.
 IPR005766; P5_carboxy_syn. 
Pfam
 PF00696; AA_kinase
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00902; GLUTAMATE_5_KINASE
 PS01223; PROA 
PRINTS
 PR00474; GLU5KINASE.