| Tag | Content |
|---|
| CPLM ID | CPLM-003536 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NADH-quinone oxidoreductase subunit M |
Protein Synonyms/Alias | NADH dehydrogenase I subunit M; NDH-1 subunit M; NUO13 |
Gene Name | nuoM |
Gene Synonyms/Alias | b2277; JW2272 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 380 | MMGGLWSKMKWLPAL | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. |
Sequence Annotation | |
Keyword | Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD; Oxidoreductase; Quinone; Reference proteome; Transmembrane; Transmembrane helix; Ubiquinone. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 509 AA |
Protein Sequence | MLLPWLILIP FIGGFLCWQT ERFGVKVPRW IALITMGLTL ALSLQLWLQG GYSLTQSAGI 60
PQWQSEFDMP WIPRFGISIH LAIDGLSLLM VVLTGLLGVL AVLCSWKEIE KYQGFFHLNL 120
MWILGGVIGV FLAIDMFLFF FFWEMMLVPM YFLIALWGHK ASDGKTRITA ATKFFIYTQA 180
SGLVMLIAIL ALVFVHYNAT GVWTFNYEEL LNTPMSSGVE YLLMLGFFIA FAVKMPVVPL 240
HGWLPDAHSQ APTAGSVDLA GILLKTAAYG LLRFSLPLFP NASAEFAPIA MWLGVIGIFY 300
GAWMAFAQTD IKRLIAYTSV SHMGFVLIAI YTGSQLAYQG AVIQMIAHGL SAAGLFILCG 360
QLYERIHTRD MRMMGGLWSK MKWLPALSLF FAVATLGMPG TGNFVGEFMI LFGSFQVVPV 420
ITVISTFGLV FASVYSLAML HRAYFGKAKS QIASQELPGM SLRELFMILL LVVLLVLLGF 480
YPQPILDTSH SAIGNIQQWF VNSVTTTRP 509 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:EcoCyc. GO:0045272; C:plasma membrane respiratory chain complex I; IDA:EcoCyc. GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. GO:0048039; F:ubiquinone binding; IDA:EcoCyc. GO:0009060; P:aerobic respiration; IMP:EcoCyc. GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. GO:0015990; P:electron transport coupled proton transport; IMP:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |