CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006522
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear pore complex protein Nup214 
Protein Synonyms/Alias
 214 kDa nucleoporin; Nucleoporin Nup214; Protein CAN 
Gene Name
 NUP214 
Gene Synonyms/Alias
 CAIN; CAN; KIAA0023 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
654PVPSMVQKSPRITPPubiquitination[1]
680LQPAVAEKQGHQWKDubiquitination[1]
919TTIESHTKSLPKVPAubiquitination[1]
942QLRNFLAKRKTPPVRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. 
Sequence Annotation
 REPEAT 41 93 Blade 1.
 REPEAT 94 150 Blade 2.
 REPEAT 151 193 Blade 3.
 REPEAT 194 239 Blade 4.
 REPEAT 240 303 Blade 5.
 REPEAT 304 359 Blade 6.
 REPEAT 360 404 Blade 7.
 REGION 41 404 Seven-bladed beta propeller.
 REGION 481 2076 11 X 5 AA approximate repeats.
 REGION 740 768 Leucine-zipper 1.
 REGION 861 882 Leucine-zipper 2.
 REGION 1409 2084 18 X 4 AA approximate repeats.
 REGION 1427 2085 11 X 3 AA approximate repeats.
 MOD_RES 430 430 Phosphoserine.
 MOD_RES 433 433 Phosphoserine.
 MOD_RES 434 434 Phosphothreonine.
 MOD_RES 437 437 Phosphothreonine.
 MOD_RES 439 439 Phosphothreonine.
 MOD_RES 651 651 Phosphoserine.
 MOD_RES 657 657 Phosphoserine.
 MOD_RES 666 666 Phosphoserine.
 MOD_RES 670 670 Phosphothreonine.
 MOD_RES 678 678 Phosphoserine.
 MOD_RES 940 940 Phosphoserine.
 MOD_RES 970 970 Phosphoserine.
 MOD_RES 974 974 Phosphoserine.
 MOD_RES 989 989 Phosphoserine.
 MOD_RES 1023 1023 Phosphoserine.
 MOD_RES 1045 1045 Phosphoserine.
 MOD_RES 1081 1081 Phosphoserine.
 MOD_RES 1134 1134 Phosphothreonine.
 MOD_RES 1150 1150 Phosphothreonine.
 MOD_RES 1156 1156 Phosphothreonine.
 MOD_RES 1181 1181 Phosphoserine.
 MOD_RES 1312 1312 Phosphothreonine.
 MOD_RES 1963 1963 Phosphoserine.
 MOD_RES 1985 1985 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Chromosomal rearrangement; Coiled coil; Complete proteome; Glycoprotein; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Proto-oncogene; Reference proteome; Repeat; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2090 AA 
Protein Sequence
MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ 60
IFPTKNLLIQ NKPGDDPNKI VDKVQGLLVP MKFPIHHLAL SCDNLTLSAC MMSSEYGSII 120
AFFDVRTFSN EAKQQKRPFA YHKLLKDAGG MVIDMKWNPT VPSMVAVCLA DGSIAVLQVT 180
ETVKVCATLP STVAVTSVCW SPKGKQLAVG KQNGTVVQYL PTLQEKKVIP CPPFYESDHP 240
VRVLDVLWIG TYVFAIVYAA ADGTLETSPD VVMALLPKKE EKHPEIFVNF MEPCYGSCTE 300
RQHHYYLSYI EEWDLVLAAS AASTEVSILA RQSDQINWES WLLEDSSRAE LPVTDKSDDS 360
LPMGVVVDYT NQVEITISDE KTLPPAPVLM LLSTDGVLCP FYMINQNPGV KSLIKTPERL 420
SLEGERQPKS PGSTPTTPTS SQAPQKLDAS AAAAPASLPP SSPAAPIATF SLLPAGGAPT 480
VFSFGSSSLK SSATVTGEPP SYSSGSDSSK AAPGPGPSTF SFVPPSKASL APTPAASPVA 540
PSAASFSFGS SGFKPTLEST PVPSVSAPNI AMKPSFPPST SAVKVNLSEN SSQSAPPMSP 600
FSSASKPAAS GPLSHPTPLS APPSSVPLKS SVLPSPSGRS AQGSSSPVPS MVQKSPRITP 660
PAAKPGSPQA KSLQPAVAEK QGHQWKDSDP VMAGIGEEIA HFQKELEELK ARTSKACFQV 720
GTSEEMKMLR TESDDLHTFL LEIKETTESL HGDISSLKTT LLEGFAGVEE AREQNERNRD 780
SGYLHLLYKR PLDPKSEAQL QEIRRLHQYV KFAVQDVNDV LDLEWDQHLE QKKKQRHLLV 840
PERETLFNTL ANNREIINQQ RKRLNHLVDS LQQLRLYKQT SLWSLSSAVP SQSSIHSFDS 900
DLESLCNALL KTTIESHTKS LPKVPAKLSP MKQAQLRNFL AKRKTPPVRS TAPASLSRSA 960
FLSQRYYEDL DEVSSTSSVS QSLESEDART SCKDDEAVVQ APRHAPVVRT PSIQPSLLPH 1020
AAPFAKSHLV HGSSPGVMGT SVATSASKII PQGADSTMLA TKTVKHGAPS PSHPISAPQA 1080
AAAAALRRQM ASQAPAVNTL TESTLKNVPQ VVNVQELKNN PATPSTAKTP HPVLTPVAAN 1140
QAKQGSLINS LKPSGPTPAS GQLSSGDKAS GTAKIETAVT STPSASGQFS KPFSFSPSGT 1200
GFNFGIITPT PSSNFTAAQG ATPSTKESSQ PDAFSSGGGS KPSYEAIPES SPPSGITSAS 1260
NTTPGEPAAS SSRPVAPSGT ALSTTSSKLE TPPSKLGELL FPSSLAGETL GSFSGLRVGQ 1320
ADDSTKPTNK ASSTSLTSTQ PTKTSGVPSG FNFTAPPVLG KHTEPPVTSS ATTTSVAPPA 1380
ATSTSSTAVF GSLPVTSAGS SGVISFGGTS LSAGKTSFSF GSQQTNSTVP PSAPPPTTAA 1440
TPLPTSFPTL SFGSLLSSAT TPSLPMSAGR STEEATSSAL PEKPGDSEVS ASAASLLEEQ 1500
QSAQLPQAPP QTSDSVKKEP VLAQPAVSNS GTAASSTSLV ALSAEATPAT TGVPDARTEA 1560
VPPASSFSVP GQTAVTAAAI SSAGPVAVET SSTPIASSTT SIVAPGPSAE AAAFGTVTSG 1620
SSVFAQPPAA SSSSAFNQLT NNTATAPSAT PVFGQVAAST APSLFGQQTG STASTAAATP 1680
QVSSSGFSSP AFGTTAPGVF GQTTFGQASV FGQSASSAAS VFSFSQPGFS SVPAFGQPAS 1740
STPTSTSGSV FGAASSTSSS SSFSFGQSSP NTGGGLFGQS NAPAFGQSPG FGQGGSVFGG 1800
TSAATTTAAT SGFSFCQASG FGSSNTGSVF GQAASTGGIV FGQQSSSSSG SVFGSGNTGR 1860
GGGFFSGLGG KPSQDAANKN PFSSASGGFG STATSNTSNL FGNSGAKTFG GFASSSFGEQ 1920
KPTGTFSSGG GSVASQGFGF SSPNKTGGFG AAPVFGSPPT FGGSPGFGGV PAFGSAPAFT 1980
SPLGSTGGKV FGEGTAAASA GGFGSLAMSL SPTLKGRLLL MRPKAGGGRE QAAPGRKSNE 2040
SRSLGHLCME RALTSPLKVW EQQQHHILRH ARESECPHFR ITVPTDFWFW DPE 2093 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005643; C:nuclear pore; TAS:ProtInc.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005487; F:nucleocytoplasmic transporter activity; IEA:Compara.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0015758; P:glucose transport; TAS:Reactome.
 GO:0006406; P:mRNA export from nucleus; IEA:Compara.
 GO:0016071; P:mRNA metabolic process; TAS:Reactome.
 GO:0006611; P:protein export from nucleus; IMP:MGI.
 GO:0006606; P:protein import into nucleus; IEA:Compara.
 GO:0051726; P:regulation of cell cycle; IEA:Compara.
 GO:0010827; P:regulation of glucose transport; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 
Interpro
 IPR026054; Nucleoporin.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat. 
Pfam
  
SMART
 SM00320; WD40 
PROSITE
  
PRINTS