CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042246
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ferrochelatase 
Protein Synonyms/Alias
  
Gene Name
 Fech 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
291TVQKVMEKLSYSNPYacetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019
Functional Description
 Catalyzes the ferrous insertion into protoporphyrin IX (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Heme biosynthesis; Iron; Lyase; Porphyrin biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 424 AA 
Protein Sequence
MLSAGTNMAA ALRAAGGLLR GPLVHGSLKT HQPWRCQLGT AAAVTTSTET AQRTKSAKPQ 60
VQPEKRKPKT GILMLNMGGP ETLGEVHDFL LRLFLDRDLM TLPIQNKLAP FIAKRRTPKI 120
QEQYRRIGGG SPIKMWTSTQ GEGMVKLLDD LSPDTAPHKY YIGFRYVHPL TEEAIEEMER 180
DGLQRAIAFT QYPQYSCSTT GSSLNAIYRY YNEVGKKPTM KWSTIDRWPT HPLLIQCFAD 240
HILKELDHFP TEKRSEVVIL FSAHSLPMSV VNRGDPYPQE VGATVQKVME KLSYSNPYRL 300
VWQSKVGPVP WLGPQTDEAI KGLCERGRKN ILLVPIAFTS DHIETLYELD IEYSQVLAKE 360
CGAENIRRAE SLNGNPLFSK ALADLVHSHI QSNKLCSKQL TLNCPLCVNP VCRETKSFFT 420
NQQL 424 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004325; F:ferrochelatase activity; IEA:EC.
 GO:0020037; F:heme binding; IEA:Compara.
 GO:0005506; F:iron ion binding; IEA:Compara.
 GO:0030350; F:iron-responsive element binding; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0009589; P:detection of UV; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IEA:Compara.
 GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
 GO:0055072; P:iron ion homeostasis; IEA:Compara.
 GO:0046501; P:protoporphyrinogen IX metabolic process; IEA:Compara.
 GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme; IEA:Compara.
 GO:0046984; P:regulation of hemoglobin biosynthetic process; IEA:Compara.
 GO:0034379; P:very-low-density lipoprotein particle assembly; IEA:Compara. 
Interpro
 IPR001015; Ferrochelatase.
 IPR019772; Ferrochelatase_AS. 
Pfam
 PF00762; Ferrochelatase 
SMART
  
PROSITE
 PS00534; FERROCHELATASE 
PRINTS