| Tag | Content |
|---|
| CPLM ID | CPLM-010954 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Voltage-dependent L-type calcium channel subunit alpha-1S |
Protein Synonyms/Alias | Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; ROB1; Voltage-gated calcium channel subunit alpha Cav1.1 |
Gene Name | Cacna1s |
Gene Synonyms/Alias | Cach1; Cacn1; Cacnl1a3; Cchl1a3 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 6 | **VPTTAKLKIDEFE | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle. |
Sequence Annotation | REPEAT 73 355 III.
REPEAT 392 671 IV.
REGION 275 364 Dihydropyridine binding (By similarity).
REGION 624 690 Dihydropyridine binding (By similarity).
REGION 636 679 Phenylalkylamine binding (By similarity).
MOD_RES 679 679 Phosphoserine; by PKA (Potential).
MOD_RES 904 904 Phosphoserine (By similarity).
CARBOHYD 428 428 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Calcium; Calcium channel; Calcium transport; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1146 AA |
Protein Sequence | VPTTAKLKID EFESNVNEVK DPYPSADFPG DDEEDEPEIP ASPRPRPLAE LQLKEKAVPI 60
PEASSFFIFS PTNKIRVLCH RIVNATWFTN FILLFILLSS AALAAEDPIR ADSMRNQILE 120
YFDYVFTAVF TVEIVLKMTT YGAFLHKGSF CRNYFNILDL LVVAVSLISM GLESSAISVV 180
KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIVL VTTLLQFMFA CIGVQLFKGK 240
FYSCNDLSKM TEEECRGYYY IYKDGDPTQI ELRPRQWIHN DFHFDNVLSA MMSLFTVSTF 300
EGWPQLLYKA IDSNEEDTGP VYNNRVEMAI FFIIYIILIA FFMMNIFVGF VIVTFQEQGE 360
TEYKNCELDK NQRQCVQYAL KARPLRCYIP KNPYQYQVWY VVTSSYFEYL MFALIMLNTI 420
CLGMQHYNQS EQMNHISDIL NVAFTIIFTL EMILKLIAFK PRGYFGDPWN VFDFLIVIGS 480
IIDVILSEID TLLASSGGLY CLGGGCGNVD PDESARISSA FFRLFRVMRL IKLLSRAEGV 540
RTLLWTFIKS FQALPYVALL IVMLFFIYAV IGMQMFGKIA MVDGTQINRN NNFQTFPQAV 600
LLLFRCATGE AWQEILLACS YGKRCDPESD YAPGEEYACG TNFAYYYFIS FYMLCAFLII 660
NLFVAVIMDN FDYLTRDWSI LGPHHLDEFK AIWAEYDPEA KGRIKHLDVV TLLRRIQPPL 720
GFGKFCPHRV ACKRLVGMNM PLNSDGTVTF NATLFALVRT ALKIKTEGNF EQANEELRAI 780
IKKIWKRTSM KLLDQVIPPI GDDEVTVGKF YATFLIQEHF RKFMKRQEEY YGYRPKKDTV 840
QIQAGLRTIE EEAAPEIHRA ISGDLTAEEE LERAMVEAAM EEGIFRRTGG LFGQVDNFLE 900
RTNSLPPVMA NQRPLQFAEM EMEELESPVF LEDFPQNPGT HPLARANTNN ANANVAYGNS 960
SHRNSPVFSS IRYERELLEE AGRPVTREGP FSQPCSVSGV NSRSHVDKLE RQMSQRRMPK 1020
GQVPPSPCQL SQEKHPVHEE GKGPRSWSTE TSDSESFEER VPRNSAHKCT APATTMLIQE 1080
ALVRGGLDSL AADANFVMAT GQALADACQM EPEEVEVAAT ELLKRESPKG GPCPGSLEPK 1140
VLPWAA 1146 |
Gene Ontology | GO:0042383; C:sarcolemma; IDA:RGD. GO:0005891; C:voltage-gated calcium channel complex; IDA:RGD. GO:0008331; F:high voltage-gated calcium channel activity; IDA:RGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0001503; P:ossification; NAS:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |