| Tag | Content |
|---|
| CPLM ID | CPLM-021022 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Iodotyrosine dehalogenase 1 |
Protein Synonyms/Alias | IYD-1 |
Gene Name | Iyd |
Gene Synonyms/Alias | Dehal1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 95 | EFYELLNKRRSVRFI | ubiquitination | [1] | | 159 | EEEINYMKRMGKRWV | ubiquitination | [1] | | 170 | KRWVTDLKKLRTNWI | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity). |
Sequence Annotation | NP_BIND 96 100 FMN.
NP_BIND 123 125 FMN.
NP_BIND 232 235 FMN.
BINDING 100 100 Substrate.
BINDING 157 157 Substrate.
BINDING 178 178 Substrate.
BINDING 275 275 FMN. |
Keyword | 3D-structure; Complete proteome; Flavoprotein; FMN; Membrane; NADP; Oxidoreductase; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 285 AA |
Protein Sequence | MFLLTPVLVA VVCILVVWVF KNADRNLEKK KEEAQVQPWV DEDLKDSTED LQVEEDAEEW 60
QEAEESVEHI PFSHTRYPEQ EMRMRSQEFY ELLNKRRSVR FISSEHVPME VIENVIKAAG 120
TAPSGAHTEP WTFVVVKDPD MKHKIREIIE EEEEINYMKR MGKRWVTDLK KLRTNWIKEY 180
LDTAPVLILI FKQVHGFAAN GKKKVHYYNE ISVSIACGLL LAALQNAGLV TVTTTPLNCG 240
PRLRVLLGRP SHEKLLVLLP VGYPSRDATV PDLKRKALDQ IMVTV 285 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004447; F:iodide peroxidase activity; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |