CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035258
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone deacetylase 
Protein Synonyms/Alias
  
Gene Name
 Hdac1l 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
79YHSDDYIKFLRSIRPacetylation[1]
94DNMSEYSKQMQRFNVacetylation[1]
207VMTVSFHKYGEYFPGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Chromatin regulator; Complete proteome; Hydrolase; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 491 AA 
Protein Sequence
RAASKMAQTQ GTERKVCYYY DGDVGNYYYG QGHPMKPHRI RMTHNLLLNY GLYRKMEIYR 60
PHKANAEEMT KYHSDDYIKF LRSIRPDNMS EYSKQMQRFN VGEDCPVFDG LFEFCQLSTG 120
GSVASAVKLN KQQTDIAVNW AGGLHYAKKS EASGFCYVND IVLAILELLK YHQRVLYIDI 180
DIHHGDGDGV EEAFYTTDRV MTVSFHKYGE YFPGTGDLRD IGAGKGKYYA VNYPLRDGID 240
DESYEAIFKP VMSKVMEMFQ PSAVVLQCGS DSLSGDRLGC FNLTIKGHAK CVEFVKSFNL 300
PMLMLGGDGY TIHNVARCWT YETAVALDTE IPNELPYNDY FEYFGPDFKL HISPSNMTNQ 360
NTNEYLEKIK QRLFENLRML PHTPGVQMQA IPEDAIPEES GDEDEEDPDK PISICSSDKC 420
IACEEEFPDS DEEGEGGREN SSNFKKAKRV KTEDEKEKDP EEKKEVTEEE KTKEEKPEAK 480
GVKEESSLVR P 491 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.
 GO:0097372; F:NAD-dependent histone deacetylase activity (H3-K18 specific); IEA:EC.
 GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.
 GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.
 GO:0070932; P:histone H3 deacetylation; IEA:GOC.
 GO:0070933; P:histone H4 deacetylation; IEA:GOC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000286; His_deacetylse.
 IPR003084; His_deacetylse_1.
 IPR023801; His_deacetylse_dom. 
Pfam
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01270; HDASUPER.
 PR01271; HISDACETLASE.