UniProt Accession

 SLU7_MOUSE; Q8BHJ9; Q3KQQ3; Q5SRU1; Q63ZX3; Q6P923; Q8BL59; Q8BXD5; Q8R5C1; Q91YV6 

Genbank Protein ID

 AK029117; AK046262; AK047597; AK049178; AL670472; AL670472; BC013810; BC023057; BC060954; BC082780; BC106099 

Genbank Nucleotide ID

 BAC26306.1; BAC32662.1; BAC33093.1; BAC33589.1; CAI24830.1; CAI24831.1; AAH13810.1; AAH23057.1; AAH60954.1; AAH82780.1; AAI06100.1 

Protein Name

 Pre-mRNA-splicing factor SLU7 

Protein Synonyms/Alias

  

Gene Name

 Slu7 

Gene Synonyms/Alias

 D11Ertd730e 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
302	NPYANAGKNPDEVSY	acetylation	[1, 2, 3]
302	NPYANAGKNPDEVSY	ubiquitination	[4]
539	EARLLHVKEIMQIDE	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation (By similarity). 

Sequence Annotation

 ZN_FING 118 135 CCHC-type.
 MOTIF 129 169 Bipartite nuclear localization signal (By
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 215 215 Phosphoserine.
 MOD_RES 227 227 Phosphoserine (By similarity).
 MOD_RES 235 235 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 585 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016607; C:nuclear speck; ISS:HGNC.
 GO:0030532; C:small nuclear ribonucleoprotein complex; ISS:HGNC.
 GO:0005681; C:spliceosomal complex; ISS:HGNC.
 GO:0030628; F:pre-mRNA 3'-splice site binding; ISS:HGNC.
 GO:0000386; F:second spliceosomal transesterification activity; ISS:HGNC.
 GO:0008270; F:zinc ion binding; ISS:HGNC.
 GO:0000380; P:alternative mRNA splicing, via spliceosome; ISS:HGNC.
 GO:0033554; P:cellular response to stress; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:Compara.
 GO:0000389; P:mRNA 3'-splice site recognition; ISS:HGNC. 

Interpro

 IPR021715; Slu7.
 IPR001878; Znf_CCHC. 

Pfam

 PF11708; Slu7 

SMART

 SM00343; ZnF_C2HC 

PROSITE

 PS50158; ZF_CCHC 

PRINTS