UniProt Accession

 PIN1_MOUSE; Q9QUR7; Q543B3 

Genbank Protein ID

 AB009691; AB009692; AK002665; AK003369; AK054045; AK150652; AK160228; BC038254 

Genbank Nucleotide ID

 BAA87037.1; BAA87038.1; BAB22270.1; BAB22743.1; BAC35631.1; BAE29739.1; BAE35702.1; AAH38254.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 

Protein Synonyms/Alias

 Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1 

Gene Name

 Pin1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	KLPPGWEKRMSRSSG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation (By similarity). Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (By similarity). Binds and targets PML for degradation in a phosphorylation-dependent manner (By similarity). 

Sequence Annotation

 DOMAIN 5 39 WW.
 DOMAIN 54 165 PpiC.
 MOD_RES 48 48 N6-acetyllysine (By similarity).
 MOD_RES 73 73 Phosphoserine; by DAPK1 (By similarity).
 MOD_RES 110 110 Phosphoserine (By similarity).  

Keyword

 Acetylation; Cell cycle; Complete proteome; Cytoplasm; Isomerase; Nucleus; Phosphoprotein; Reference proteome; Rotamase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 165 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:2000146; P:negative regulation of cell motility; IEA:Compara.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0001934; P:positive regulation of protein phosphorylation; IEA:Compara.
 GO:0032321; P:positive regulation of Rho GTPase activity; IEA:Compara.
 GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; IEA:Compara.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0042127; P:regulation of cell proliferation; IMP:MGI.
 GO:0032465; P:regulation of cytokinesis; IMP:MGI.
 GO:0060393; P:regulation of pathway-restricted SMAD protein phosphorylation; IEA:Compara. 

Interpro

 IPR000297; PPIase_PpiC.
 IPR023058; PPIase_PpiC_CS.
 IPR001202; WW_dom. 

Pfam

 PF00639; Rotamase
 PF00397; WW 

SMART

 SM00456; WW 

PROSITE

 PS01096; PPIC_PPIASE_1
 PS50198; PPIC_PPIASE_2
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 

PRINTS