| Tag | Content |
|---|
| CPLM ID | CPLM-006970 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Signal recognition particle subunit SRP68 |
Protein Synonyms/Alias | Signal recognition particle 68 kDa protein homolog |
Gene Name | SRP68 |
Gene Synonyms/Alias | YPL243W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 531 | LKNLFPLKPKMLPIP | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. |
Sequence Annotation | |
Keyword | Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 599 AA |
Protein Sequence | MVAYSPIIAT YGNRAEQFLE TDSDFAKYHA KLNKKLQHLR SRCHLVTKDT KKYSSKNKYG 60
EINSEDYDNK TKLIGVLILL HAERDLALAE TLKLRARQRG KLKKSEEKVL STRLKKACKT 120
ADKLVNVTQN EQQWITRAQY LAFAKLVHSE YLINGKRFKR KDNAKISNNL ALVFAALEHL 180
KNLSLLAEEV VDNIVNKYQY SLKQYAGNLI TTPEINNFIV ERVQSDENKD DELVKLLLDN 240
GFNMKKITTS TEDQKVTTNI NWRSFNAKII DAEVAQFLEQ GLSIHPTQIT QYTQRLSKLE 300
KALDRHEFFI ANHDDQDDID EMVENSSENN QIILAYIKYN ILLTSISRER DLFTHLWNQW 360
LKLNTSLPSK LTKYKEMERI VKNLTKYLSD IMELPGVYSD DELLSQLDLC KLYFQLFLNT 420
GCLSVLYQSK GRYMEALALY VDAYRRLENK LSEIESLDEI LLPANLLSLN SVRSLQKRIE 480
NGGNSVITLA EYEKRNHGGS LGKYDLTVIE KLDSKKILPT DIQLKNLFPL KPKMLPIPSK 540
PTLFDLAFNY ITYDKQEPSA SQVKDSVTET ESISQTPISN EQTEGEPKKK RGFLGLFGR 599 |
Gene Ontology | GO:0034399; C:nuclear periphery; IDA:SGD. GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IDA:SGD. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0005048; F:signal sequence binding; IPI:SGD. GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IC:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |