CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009687
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcineurin subunit B type 1 
Protein Synonyms/Alias
 Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1 
Gene Name
 Ppp3r1 
Gene Synonyms/Alias
 Cna2; Cnb 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
85GVSQFSVKGDKEQKLubiquitination[1]
125MMVGNNLKDTQLQQIacetylation[2]
125MMVGNNLKDTQLQQIubiquitination[1]
135QLQQIVDKTIINADKacetylation[2]
142KTIINADKDGDGRISacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. 
Sequence Annotation
 DOMAIN 18 51 EF-hand 1.
 DOMAIN 50 85 EF-hand 2.
 DOMAIN 87 122 EF-hand 3.
 DOMAIN 128 163 EF-hand 4.
 MOD_RES 106 106 Phosphotyrosine (By similarity).
 LIPID 2 2 N-myristoyl glycine.  
Keyword
 Alternative splicing; Calcium; Complete proteome; Lipoprotein; Metal-binding; Myristate; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 170 AA 
Protein Sequence
MGNEASYPLE MCSHFDADEI KRLGKRFKKL DLDNSGSLSV EEFMSLPELQ QNPLVQRVID 60
IFDTDGNGEV DFKEFIEGVS QFSVKGDKEQ KLRFAFRIYD MDKDGYISNG ELFQVLKMMV 120
GNNLKDTQLQ QIVDKTIINA DKDGDGRISF EEFCAVVGGL DIHKKMVVDV 170 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004721; F:phosphoprotein phosphatase activity; IDA:RGD.
 GO:0006470; P:protein dephosphorylation; IDA:RGD. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF13499; EF_hand_5
 PF00036; efhand 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS