CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023701
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine deaminase 
Protein Synonyms/Alias
 Guanase; Guanine aminase; Guanine aminohydrolase; GAH; p51-nedasin 
Gene Name
 GDA 
Gene Synonyms/Alias
 KIAA1258 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
201FVSEMLQKNYSRVKPubiquitination[1]
252RDEVEAVKNLYPSYKubiquitination[1]
259KNLYPSYKNYTSVYDubiquitination[1]
267NYTSVYDKNNLLTNKubiquitination[1]
361LINKVNEKSLTLKEVubiquitination[1]
366NEKSLTLKEVFRLATubiquitination[1]
445EEVYVGGKQVVPFSSubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity). 
Sequence Annotation
 METAL 82 82 Zinc; via tele nitrogen.
 METAL 84 84 Zinc; via tele nitrogen.
 METAL 240 240 Zinc; via tele nitrogen.
 METAL 330 330 Zinc (By similarity).
 BINDING 87 87 Substrate.
 BINDING 213 213 Substrate.
 BINDING 243 243 Substrate.
 BINDING 279 279 Substrate.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 454 AA 
Protein Sequence
MCAAQMPPLA HIFRGTFVHS TWTCPMEVLR DHLLGVSDSG KIVFLEEASQ QEKLAKEWCF 60
KPCEIRELSH HEFFMPGLVD THIHASQYSF AGSSIDLPLL EWLTKYTFPA EHRFQNIDFA 120
EEVYTRVVRR TLKNGTTTAC YFATIHTDSS LLLADITDKF GQRAFVGKVC MDLNDTFPEY 180
KETTEESIKE TERFVSEMLQ KNYSRVKPIV TPRFSLSCSE TLMGELGNIA KTRDLHIQSH 240
ISENRDEVEA VKNLYPSYKN YTSVYDKNNL LTNKTVMAHG CYLSAEELNV FHERGASIAH 300
CPNSNLSLSS GFLNVLEVLK HEVKIGLGTD VAGGYSYSML DAIRRAVMVS NILLINKVNE 360
KSLTLKEVFR LATLGGSQAL GLDGEIGNFE VGKEFDAILI NPKASDSPID LFYGDFFGDI 420
SEAVIQKFLY LGDDRNIEEV YVGGKQVVPF SSSV 454 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0008892; F:guanine deaminase activity; EXP:Reactome.
 GO:0008270; F:zinc ion binding; TAS:ProtInc.
 GO:0006147; P:guanine catabolic process; IEA:UniProtKB-UniPathway.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0006144; P:purine nucleobase metabolic process; TAS:Reactome.
 GO:0006195; P:purine nucleotide catabolic process; TAS:Reactome. 
Interpro
 IPR006680; Amidohydro_1.
 IPR014311; Guanine_deaminase. 
Pfam
 PF01979; Amidohydro_1 
SMART
  
PROSITE
  
PRINTS