CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004024
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Annexin A3 
Protein Synonyms/Alias
 35-alpha calcimedin; Annexin III; Annexin-3; Inositol 1,2-cyclic phosphate 2-phosphohydrolase; Lipocortin III; Placental anticoagulant protein III; PAP-III 
Gene Name
 ANXA3 
Gene Synonyms/Alias
 ANX3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29VDAEAIQKAIRGIGTubiquitination[1]
58AQRQLIVKEYQAAYGubiquitination[1]
104KQLKKSMKGAGTNEDubiquitination[1, 2]
176KVDEHLAKQDAQILYubiquitination[1]
184QDAQILYKAGENRWGubiquitination[1, 2]
210LRSFPQLKLTFDEYRubiquitination[2, 3, 4]
263ERLHRALKGIGTDEFubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. 
Sequence Annotation
 REPEAT 27 87 Annexin 1.
 REPEAT 99 159 Annexin 2.
 REPEAT 183 243 Annexin 3.
 REPEAT 258 318 Annexin 4.
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 3D-structure; Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Phospholipase A2 inhibitor; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 323 AA 
Protein Sequence
MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN AQRQLIVKEY 60
QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK KSMKGAGTNE DALIEILTTR 120
TSRQMKDISQ AYYTVYKKSL GDDISSETSG DFRKALLTLA DGRRDESLKV DEHLAKQDAQ 180
ILYKAGENRW GTDEDKFTEI LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL 240
LAIVNCVRNT PAFLAERLHR ALKGIGTDEF TLNRIMVSRS EIDLLDIRTE FKKHYGYSLY 300
SAIKSDTSGD YEITLLKICG GDD 323 
Gene Ontology
 GO:0030670; C:phagocytic vesicle membrane; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0042581; C:specific granule; IDA:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IDA:UniProtKB.
 GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
 GO:0042742; P:defense response to bacterium; IDA:UniProtKB.
 GO:0043312; P:neutrophil degranulation; IDA:UniProtKB.
 GO:0006909; P:phagocytosis; IDA:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; IDA:UniProtKB.
 GO:0010595; P:positive regulation of endothelial cell migration; IDA:UniProtKB.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB. 
Interpro
 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002390; AnnexinIII. 
Pfam
 PF00191; Annexin 
SMART
 SM00335; ANX 
PROSITE
 PS00223; ANNEXIN 
PRINTS
 PR00196; ANNEXIN.
 PR00199; ANNEXINIII.