CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000202
UniProt Accession
Genbank Protein ID
 S83320 
Genbank Nucleotide ID
Protein Name
 ELAV-like protein 4 
Protein Synonyms/Alias
 Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD 
Gene Name
 Elavl4 
Gene Synonyms/Alias
 Hud 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
95IDPKDAEKAINTLNGubiquitination[1]
209FANNPSQKSSQALLSubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity). May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR. 
Sequence Annotation
 DOMAIN 39 117 RRM 1.
 DOMAIN 125 205 RRM 2.
 DOMAIN 290 368 RRM 3.
 MOD_RES 236 236 Omega-N-methylated arginine; by CARM1.  
Keyword
 Alternative splicing; Complete proteome; Methylation; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 373 AA 
Protein Sequence
MEPQVSNGPT SNTSNGPSSN NRNCPSPMQT GAATDDSKTN LIVNYLPQNM TQEEFRSLFG 60
SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL NGLRLQTKTI KVSYARPSSA 120
SIRDANLYVS GLPKTMTQKE LEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE 180
EAIKGLNGQK PSGATEPITV KFANNPSQKS SQALLSQLYQ SPNRRYPGPL HHQAQRFRLD 240
NLLNMAYGVK RLMSGPVPPS ACPPRFSPIT IDGMTSLVGM NIPGHTGTGW CIFVYNLSPD 300
SDESVLWQLF GPFGAVNNVK VIRDFNTNKC KGFGFVTMTN YDEAAMAIAS LNGYRLGDRV 360
LQVSFKTNKA HKS 373 
Gene Ontology
 GO:0017091; F:AU-rich element binding; ISS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro. 
Interpro
 IPR006548; ELAD_HUD_SF.
 IPR002343; Hud_Sxl_RNA.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS
 PR00961; HUDSXLRNA.