| Tag | Content |
|---|
| CPLM ID | CPLM-014746 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PAP-associated domain-containing protein 5 |
Protein Synonyms/Alias | Topoisomerase-related function protein 4-2; TRF4-2 |
Gene Name | Papd5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 356 | DGGSYVAKDEVQKNM | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | DNA polymerase, probably involved in DNA repair. Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. May play a role in sister chromatid cohesion (By similarity). |
Sequence Annotation | DOMAIN 322 382 PAP-associated.
METAL 191 191 Magnesium or manganese; catalytic (By
METAL 193 193 Magnesium or manganese; catalytic (By
MOD_RES 545 545 Phosphoserine (By similarity). |
Keyword | Cell cycle; Cell division; Complete proteome; Cytoplasm; DNA synthesis; DNA-binding; DNA-directed DNA polymerase; Magnesium; Manganese; Metal-binding; Mitosis; Nucleotidyltransferase; Nucleus; Phosphoprotein; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 633 AA |
Protein Sequence | MFRSGERPLG GLAVPAEQRD FLPLETTNNN NNHHQPAAWA RRASAGPSAS PVPSAPSSPR 60
PAAALPASES TDPASGSSNK RKRDNKASTY GLNYSLLQPS GGRAAGGGRA DGGGGVYSGT 120
PWKRRNYNQG VVGLHEEISD FYEYMSPRPE EEKMRMEVVS RIESVIKELW PSADVQIFGS 180
FKTGLYLPTS DIDLVVFGKW ENLPLWTLEE ALRKHKVADE DSVKVLDKAT VPIIKLTDSF 240
TEVKVDISFN VQNGVRAADL IKDFTKKYPV LPYLVLVLKQ FLLQRDLNEV FTGGIGSYSL 300
FLMAVSFLQL HPREDACIPN TNYGVLLIEF FELYGRHFNY LKTGIRIKDG GSYVAKDEVQ 360
KNMLDGYRPS MLYIEDPLQP GNDVGRSSYG AMQVKQAFDY AYVVLSHAVS PIAKYYPNNE 420
TESILGRIIR VTDEVATYRD WISKQWGLQN RPEPSCNGNG VTLIVDTQQL DKCNNNLSEE 480
KEALGKCRSN ASEPLSKHSS NSSSGPVSSS SATQSSSSDV DSDATPCKTP KQLLCRPPTV 540
TRVGSQDVSL EVSQAVGKMQ STQTTNTPNN ANKSQHGSAR LFRSSSKGFQ GTAQTSHGAL 600
MTSKQHQGKS NTQYYHGKKR RHKRDAPLSE LCR 633 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0006260; P:DNA replication; IEA:UniProtKB-KW. GO:0071044; P:histone mRNA catabolic process; ISS:UniProtKB. GO:0007067; P:mitosis; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |