| Tag | Content |
|---|
| CPLM ID | CPLM-017760 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alanine aminotransferase 1 |
Protein Synonyms/Alias | ALT1; Glutamate pyruvate transaminase 1; GPT 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1 |
Gene Name | Gpt |
Gene Synonyms/Alias | Gpt1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 57 | QELRQGVKKPFTEVI | ubiquitination | [1] | | 105 | PDFPEDAKRRAERIL | ubiquitination | [1] | | 291 | SQFHSFKKVLTEMGP | ubiquitination | [1] | | 338 | NMDAEVQKQMAKLMS | ubiquitination | [1] | | 342 | EVQKQMAKLMSVRLC | ubiquitination | [1] | | 373 | TPSEPSFKQFQAERQ | ubiquitination | [1] | | 389 | VLAELAAKAKLTEQV | ubiquitination | [1] | | 391 | AELAAKAKLTEQVFN | ubiquitination | [1] | | 423 | PQIQLPLKAVQRAQD | ubiquitination | [1] | | 476 | TILPPMEKLRVLLEK | ubiquitination | [1] | | 483 | KLRVLLEKLRHFHAK | ubiquitination | [1] | | 490 | KLRHFHAKFTHEYS* | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). |
Sequence Annotation | MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 314 314 N6-(pyridoxal phosphate)lysine (By |
Keyword | Acetylation; Aminotransferase; Complete proteome; Cytoplasm; Pyridoxal phosphate; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 496 AA |
Protein Sequence | MASQRNDRIQ ASRNGLKGKV LTLDTMNPCV RRVEYAVRGP IVQRALELEQ ELRQGVKKPF 60
TEVIRANIGD AQAMGQRPIT FFRQVLALCV YPNLLSSPDF PEDAKRRAER ILQACGGHSL 120
GAYSISSGIQ PIREDVAQYI ERRDGGIPAD PNNIFLSTGA SDAIVTMLKL LVAGEGRART 180
GVLIPIPQYP LYSAALAELD AVQVDYYLDE ERAWALDIAE LRRALCQARD RCCPRVLCVI 240
NPGNPTGQVQ TRECIEAVIR FAFEEGLFLM ADEVYQDNVY AEGSQFHSFK KVLTEMGPPY 300
ATQQELASFH SVSKGYMGEC GFRGGYVEVV NMDAEVQKQM AKLMSVRLCP PVPGQALMGM 360
VVSPPTPSEP SFKQFQAERQ EVLAELAAKA KLTEQVFNEA PGIRCNPVQG AMYSFPQIQL 420
PLKAVQRAQD LGLAPDMFFC LCLLEETGIC VVPGSGFGQQ EGTYHFRMTI LPPMEKLRVL 480
LEKLRHFHAK FTHEYS 496 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004021; F:L-alanine:2-oxoglutarate aminotransferase activity; IEA:EC. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0009058; P:biosynthetic process; IEA:InterPro. GO:0042853; P:L-alanine catabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |