CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009761
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP synthase subunit alpha 
Protein Synonyms/Alias
 ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha 
Gene Name
 atpA 
Gene Synonyms/Alias
 Rv1308; MT1348; MTCY373.28 
Created Date
 July 27, 2013 
Organism
 Mycobacterium tuberculosis 
NCBI Taxa ID
 1773 
Lysine Modification
Position
Peptide
Type
References
499LTEEAADKLTEVIKNpupylation[1]
Reference
 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036
Functional Description
 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity). 
Sequence Annotation
 NP_BIND 172 179 ATP (By similarity).
 CROSSLNK 499 499 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 ATP synthesis; ATP-binding; Cell membrane; CF(1); Complete proteome; Hydrogen ion transport; Hydrolase; Ion transport; Isopeptide bond; Membrane; Nucleotide-binding; Reference proteome; Transport; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 549 AA 
Protein Sequence
MAELTIPADD IQSAIEEYVS SFTADTSREE VGTVVDAGDG IAHVEGLPSV MTQELLEFPG 60
GILGVALNLD EHSVGAVILG DFENIEEGQQ VKRTGEVLSV PVGDGFLGRV VNPLGQPIDG 120
RGDVDSDTRR ALELQAPSVV HRQGVKEPLQ TGIKAIDAMT PIGRGQRQLI IGDRKTGKTA 180
VCVDTILNQR QNWESGDPKK QVRCVYVAIG QKGTTIAAVR RTLEEGGAMD YTTIVAAAAS 240
ESAGFKWLAP YTGSAIAQHW MYEGKHVLII FDDLTKQAEA YRAISLLLRR PPGREAYPGD 300
VFYLHSRLLE RCAKLSDDLG GGSLTGLPII ETKANDISAY IPTNVISITD GQCFLETDLF 360
NQGVRPAINV GVSVSRVGGA AQIKAMKEVA GSLRLDLSQY RELEAFAAFA SDLDAASKAQ 420
LERGARLVEL LKQPQSQPMP VEEQVVSIFL GTGGHLDSVP VEDVRRFETE LLDHMRASEE 480
EILTEIRDSQ KLTEEAADKL TEVIKNFKKG FAATGGGSVV PDEHVEALDE DKLAKEAVKV 540
KKPAPKKKK 549 
Gene Ontology
 GO:0005618; C:cell wall; IDA:MTBBASE.
 GO:0005886; C:plasma membrane; IDA:MTBBASE.
 GO:0045261; C:proton-transporting ATP synthase complex, catalytic core F(1); IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:HAMAP.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0040007; P:growth; IMP:MTBBASE.
 GO:0042777; P:plasma membrane ATP synthesis coupled proton transport; IEA:HAMAP. 
Interpro
 IPR020003; ATPase_a/bsu_AS.
 IPR004100; ATPase_a/bsu_N.
 IPR005294; ATPase_F1-cplx_asu.
 IPR023366; ATPase_F1/A1-cplx_a_su_N.
 IPR000793; ATPase_F1/V1/A1-cplx_a/bsu_C.
 IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00006; ATP-synt_ab
 PF00306; ATP-synt_ab_C
 PF02874; ATP-synt_ab_N 
SMART
  
PROSITE
 PS00152; ATPASE_ALPHA_BETA 
PRINTS