CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045232
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coatomer protein complex, subunit epsilon, isoform CRA_g 
Protein Synonyms/Alias
 Coatomer subunit epsilon 
Gene Name
 COPE 
Gene Synonyms/Alias
 hCG_2001439 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
42INEAQRVKLSSPERDubiquitination[1]
65RAYLAQRKFGVVLDEubiquitination[1, 2, 3, 4, 5]
74GVVLDEIKPSSAPELubiquitination[1, 3]
288VLSQHLGKPPEVTNRubiquitination[2, 3, 4, 5, 6]
301NRYLSQLKDAHRSHPubiquitination[1, 2, 3, 5, 6]
311HRSHPFIKEYQAKENubiquitination[1, 6]
316FIKEYQAKENDFDRLubiquitination[1, 3, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 331 AA 
Protein Sequence
MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPERDV ERDVFLYRAY 60
LAQRKFGVVL DEIKPSSAPE LQAVRMFADY LAHESRRDSI VAELDREMSR SVDVTNTTFL 120
LMAASIYLHD QNPDAALRAL HQGDSLEWVS SPGRALHLEA QPMEAASPDG RTAMTVQILL 180
KLDRLDLARK ELKRMQDLDE DATLTQLATA WVSLATGGEK LQDAYYIFQE MADKCSPTLL 240
LLNGQAACHM AQGRWEAAEG LLQEALDKDS GYPETLVNLI VLSQHLGKPP EVTNRYLSQL 300
KDAHRSHPFI KEYQAKENDF DRLVLQYAPS A 331 
Gene Ontology
 GO:0030126; C:COPI vesicle coat; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:InterPro. 
Interpro
 IPR006822; Coatomer_esu.
 IPR011990; TPR-like_helical. 
Pfam
 PF04733; Coatomer_E 
SMART
  
PROSITE
  
PRINTS