UniProt Accession

 ODPB_HUMAN; P11177; B2R7L0; B4DDD7; Q6FH45; Q9BQ27; Q9UFK3 

Genbank Protein ID

 M34479; M19123; M54788; M34055; M34056; D90086; J03576; AL117618; CR541911; AK293153; AK313022; AC135507; CH471055; BC000439; BC001924; X57778 

Genbank Nucleotide ID

 AAA36428.1; AAA60052.1; AAA60053.1; AAA60233.1; AAA60054.1; BAA14123.1; AAA88097.1; CAB56017.1; CAG46709.1; BAG56698.1; BAG35857.1; EAW65371.1; AAH00439.1; AAH01924.1; CAA40924.1 

Protein Name

 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 

Protein Synonyms/Alias

 PDHE1-B 

Gene Name

 PDHB 

Gene Synonyms/Alias

 PHE1B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
50	AQYDGAYKVSRGLWK	ubiquitination	[1]
166	PWNSEDAKGLIKSAI	ubiquitination	[1]
209	DFLIPIGKAKIERQG	ubiquitination	[1]
318	DVPMPYAKILEDNSI	ubiquitination	[1]
329	DNSIPQVKDIIFAIK	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. 

Sequence Annotation

 BINDING 89 89 Thiamine pyrophosphate.
 MOD_RES 67 67 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Disease mutation; Glucose metabolism; Mitochondrion; Oxidoreductase; Phosphoprotein; Polymorphism; Pyruvate; Reference proteome; Thiamine pyrophosphate; Transit peptide; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 359 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0045254; C:pyruvate dehydrogenase complex; IDA:UniProtKB.
 GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; TAS:ProtInc.
 GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IDA:UniProtKB.
 GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
 GO:0010510; P:regulation of acetyl-CoA biosynthetic process from pyruvate; TAS:Reactome.
 GO:0006099; P:tricarboxylic acid cycle; IDA:UniProtKB. 

Interpro

 IPR027110; PDHB.
 IPR009014; Transketo_C/Pyr-ferredox_oxred.
 IPR015941; Transketolase-like_C.
 IPR005475; Transketolase-like_Pyr-bd.
 IPR005476; Transketolase_C. 

Pfam

 PF02779; Transket_pyr
 PF02780; Transketolase_C 

SMART

 SM00861; Transket_pyr 

PROSITE

  

PRINTS