CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035469
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Ptpn22 
Protein Synonyms/Alias
 Protein tyrosine phosphatase, non-receptor type 22 (Lymphoid) (Predicted) 
Gene Name
 Ptpn22 
Gene Synonyms/Alias
 Ptpn22_predicted; rCG_51823 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
12EILQQLLKEAQKKKIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protein phosphatase; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 804 AA 
Protein Sequence
MDQREILQQL LKEAQKKKIN REEFANEFLK LKRQSTKYKA DKIYPTTVAQ RPKNIKKNRY 60
KDILPYDHSL VELSLLTSDE DSSYINASFI KGVYGPRAYI ATQGPLSTTL LDFWRMIWEY 120
RVLVIVMACM EFEMGKKKCE RYWAEPGETQ LQFGPFSISC ETEKKKSDYK IRTLKAKFNS 180
ETRIVYQFHY KNWPDHDVPS SIDPILQLIW DMRCYQEDDC VPLCIHCSAG CGRTGVICAV 240
DYTWMLLKDG IIPKNFSVFN LIQEMRTQRP SLVQTQEQYE LVYSAVLELF KRHVDIISDN 300
HREREIQAEC SIPEQKLTIE ADSYPLDFPK NAVRDAKMTN QQSKQGAEAE STEVSSFGLR 360
TSKISAKEEL VLHSKSSPSF DCLELNCECN KAVITRNGQA RASLVVGEPL QKYQSLDFGS 420
ILFGSCPSAL PINTASRCHN SKGPVKRTKS TPFELIQQRK TNELAVEDGS SCLESQLLEH 480
GLMELQAQKV AHASSEELNY SLPRACERPA CDASCVPQDG PGALREHLCM SLAEDPYFSS 540
SPPNSAGSKM SFDLPEKQDG ATSPGAQLPA SSAASSSYSN PRDSLMESTL TSFPPPINQE 600
TAIEATSART DDEIPPPLPE RTPESFIVAE AAGEPSPSIT ESLPLAGKSG VTLECGGTSE 660
SQSHDLVAFT SSKNVELGSP KSDQHQDGSP PPPLPERTLE SFFLADEDCI QAQPMKPSSI 720
SYPETTEIST SSKQTLKTPG KSFTRSKSLK IFRNMKKSVC NSPSPSKPTE CVQPKNSSSF 780
LNFGFGTRFS KPKGPRNPPS TWNI 804 
Gene Ontology
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL.
 GO:0019900; F:kinase binding; ISS:BHF-UCL.
 GO:0004725; F:protein tyrosine phosphatase activity; ISS:BHF-UCL.
 GO:0017124; F:SH3 domain binding; ISS:BHF-UCL.
 GO:0050868; P:negative regulation of T cell activation; ISS:BHF-UCL.
 GO:0050860; P:negative regulation of T cell receptor signaling pathway; IEA:Compara.
 GO:0035644; P:phosphoanandamide dephosphorylation; ISS:BHF-UCL.
 GO:0032817; P:regulation of natural killer cell proliferation; ISS:BHF-UCL.
 GO:0030217; P:T cell differentiation; IEA:Compara.
 GO:0050852; P:T cell receptor signaling pathway; IEA:Compara. 
Interpro
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF00102; Y_phosphatase 
SMART
 SM00194; PTPc 
PROSITE
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00700; PRTYPHPHTASE.