UniProt Accession

 XPA_HUMAN; P23025; Q5T1U9; Q6LCW7; Q6LD02 

Genbank Protein ID

 D14533; BT019518; AF503166; AL445531; CH471105; BC014965; U16815; U10347; U10343; U10344; U10345; U10346 

Genbank Nucleotide ID

 BAA03403.1; AAV38325.1; AAM18969.1; CAI15428.1; EAW58855.1; AAH14965.1; AAB60404.1; AAA92883.1; AAA92883.1; AAA92883.1; AAA92883.1; AAA92883.1 

Protein Name

 DNA repair protein complementing XP-A cells 

Protein Synonyms/Alias

 Xeroderma pigmentosum group A-complementing protein 

Gene Name

 XPA 

Gene Synonyms/Alias

 XPAC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
63	TGGMANVKAAPKIID	acetylation	[1]
67	ANVKAAPKIIDTGGG	acetylation	[1]

Reference

 [1] SIRT1 regulates UV-induced DNA repair through deacetylating XPA.
 Fan W, Luo J.
 Mol Cell. 2010 Jul 30;39(2):247-58. [PMID: 20670893] 

Functional Description

 Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. 

Sequence Annotation

 ZN_FING 105 129
 REGION 4 97 Interaction with CEP164 and required for
 MOTIF 26 47 Nuclear localization signal (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 196 196 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Disease mutation; DNA damage; DNA repair; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation; Xeroderma pigmentosum; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 273 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003684; F:damaged DNA binding; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Compara.
 GO:0000718; P:nucleotide-excision repair, DNA damage removal; TAS:Reactome.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0009411; P:response to UV; IEA:Compara. 

Interpro

 IPR009061; DNA-bd_dom_put.
 IPR000465; XPA.
 IPR022656; XPA_C.
 IPR022658; XPA_CS.
 IPR022652; Znf_XPA_CS. 

Pfam

 PF05181; XPA_C
 PF01286; XPA_N 

SMART

  

PROSITE

 PS00752; XPA_1
 PS00753; XPA_2 

PRINTS